Two new metal–organic frameworks (MOFs) [Eu(Hpta)(C₂O₄)]·3H₂O (1) and {[Co(pta)]·1.5H₂O}_n (2) were prepared via reaction of the corresponding metal salts with a bifunctional organic ligand 2-(4-pyridyl)-terephthalic acid (H₂pta) under the solvothermal reaction conditions. The Eu(III)-based complex 1 is highly selective and sensitive to Cu²⁺ in the water solution, and nearly 93% of its fluorescent intensity could be quenched when the Cu²⁺ ion concentration is 10^–2 mol/L. Complex 1 has a relative high quenching constant K_SV of 1163 M⁻¹,which might be highly related to its uncoordinated nitrogen sites for the binding with Cu²⁺ ion in aqueous solution as reflected by the X-ray photoelectron spectroscopy (XPS) analysis (from 399.6 eV to 400.2 eV). Furthermore, they were used for the chronic glomerulus nephritis treatment, the biological activity and detail mechanism was investigated. The CFU assay was implemented to determine the fecal bacterial numbers of Escherichia coli (E. coli) after treated with compound 1 or 2. Afterward, the western blot was implemented to determine the autophagic levels in the renal tubular endothelial cells.

通过反应制备了两种新的金属-有机骨架[MOFs] [Eu（Hpta）（C ₂ O ₄）]·3H ₂ O（1）和{[Co（pta）]·1.5H ₂ O} _n（2）溶剂热反应条件下用双官能有机配体2-（4-吡啶基）-对苯二甲酸（H ₂ pta）制备相应的金属盐。基于Eu（III）的络合物1具有很高的选择性，并且对水溶液中的Cu ²⁺敏感，当Cu ²⁺离子浓度为10 ^–2  mol / L时，其荧光强度的近93％可以被猝灭。综合大楼1X射线光电子能谱（XPS）分析显示，其淬灭常数K _SV相对较高，为1163 M ^-1，这可能与其在水溶液中与Cu ²⁺离子结合的不协调氮原子位点高度相关（来自399.6 eV至400.2 eV）。此外，它们还用于慢性肾小球肾炎的治疗，研究了其生物学活性和详细机制。实施CFU测定以确定用化合物1或2处理后的大肠杆菌（E.coli）的粪便细菌数。之后，进行蛋白质印迹以确定肾小管内皮细胞中的自噬水平。