Recent studies suggest that patients with multiple sclerosis(MS) have low levels of neurotrophic factors such as nerve growth factor(NGF), brain-derived neurothrophic factor(BDNF) and the vitamin D-binding protein(VDBP), and exercise training may affects these factors in people with MS. The purpose of this study was to investigate the effect of a combined exercise training programon the serum levels of neurotrophic factos in women with MS. A randomized controlled clinical trial was conducted in 24 volunteer MS patients(Expanded Disability Status Scale range of 1–5). Resting serum levels of BDNF, NGF, VDBP, body composition variables, and disability scale values were determined before and after the intervention. The intervention consisted of three sessions of combined training a week for 12 weeks(two sessions of aerobic and one session of resistance training, progressively). Aerobic training consisted of interval training with 4-13 repetition of aerobic activity at 40-55% of heart rate reserve; and resistance training consisted of 8-12 repetitions with 60-80% of 1RM for eight movements. The results showed a significant decrease in body fat percentage (p=0.003) and disability scale value(p=0.007) in the experimental group. no other significant changes was observed for other variables or in the control group. This study indicates that although the combined aerobic and resistance training in three non-consecutive days per week for 12 weeks has no effect on NGF, BDNF, and VDBP; however with positive effects on the body fat percentage and disability scale value can be for women with MS.

中文翻译：

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12周同时训练对多发性硬化症女性血清NGF，BDNF和VDBP的影响

最近的研究表明，多发性硬化症（MS）患者的神经营养因子水平较低，例如神经生长因子（NGF），脑源性神经营养因子（BDNF）和维生素D结合蛋白（VDBP），运动训练可能会影响这些因素与MS患者有关。这项研究的目的是调查联合运动训练计划对MS患者血清神经营养因子水平的影响。在24名志愿者MS患者中进行了一项随机对照临床试验（扩展的残疾状态量表范围为1至5）。在干预之前和之后确定静息的血清BDNF，NGF，VDBP，身体成分变量和残疾量表值。干预包括每周三节训练，共12周（两节有氧训练和一节阻力训练，逐步进行）。有氧训练包括以心率储备的40-55％重复4-13次有氧运动的间歇训练；阻力训练包括8到12次重复运动和1RM的60-80％，共进行8次运动。结果显示，实验组的体脂百分比（p = 0.003）和残疾量表值（p = 0.007）显着降低。在其他变量或对照组中未观察到其他显着变化。这项研究表明，尽管有氧和阻力训练相结合，每周连续三周（连续12天）对NGF，BDNF和VDBP没有影响；