Being a newly emerging disease, little is known about its long-lasting post-COVID-19 consequences. The aim of this work is to assess the frequency, patterns, and determinants of persistent post-COVID-19 symptoms and to evaluate the value of a proposed novel COVID-19 symptom score. Patients with confirmed COVID-19 in a hospital-based registry were included in a cross-sectional study (the hospitals including Assiut University Hospital, Assiut Chest Hospital, Aswan University Hospital, and Aswan Specialized Hospital). The patient demographics, comorbid disorders, the mean duration since the onset of the symptoms, history of hospital or ICU admittance, and the treatment taken during the acute state, as well as symptom score before and after convalescence, were recorded. The most frequent constitutional and neurological symptoms were myalgia (60.0%), arthralgia (57.2%), restriction of daily activities (57.0%), and sleeping troubles (50.9%), followed by anorexia (42.6%), chest pain (32.6%), gastritis (32.3%), cough (29.3%), and dyspnea (29.1%). The mean total score of acute stage symptoms was 31.0 ± 16.3 while post-COVID 19 symptom score was 13.1 ± 12.6 (P < 0.001). The main determinants of the persistent post-COVID-19 symptoms were the need for oxygen therapy (P < 0.001), pre-existing hypertension (P = 0.039), chronic pulmonary disorders (P = 0.012), and any chronic comorbidity (P = 0.004). There was a correlation between the symptom score during the acute attack and post-COVID-19 stage (P < 0.001, r = 0.67). The acute phase score had 83.5% sensitivity and 73.3% specificity for the cutoff point > 18 to predict occurrence of post-COVID-19 symptoms. COVID-19 can present with a diverse spectrum of long-term post-COVID-19 symptoms. Increased acute phase symptom severity and COVID-19 symptom score > 18 together with the presence of any comorbid diseases increase the risk for persistent post-COVID-19 manifestations and severity.

中文翻译：

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持续COVID-19后症状的决定因素：新COVID-19症状评分的价值

作为一种新兴疾病，人们对其COVID-19后的长期后果知之甚少。这项工作的目的是评估COVID-19后持续出现症状的频率，模式和决定因素，并评估提议的新型COVID-19症状评分的价值。一项横断面研究（医院包括Assiut大学医院，Assiut胸科医院，Aswan大学医院和Aswan专科医院）中纳入了以医院为基础的注册表中已确认COVID-19的患者。记录患者的人口统计资料，合并症，自症状发作以来的平均持续时间，住院或ICU入院的病史以及急性期采取的治疗方法以及康复前后的症状评分。最常见的体质和神经症状是肌痛（60.0％），关节痛（57.2％），日常活动受限（57.0％）和睡眠障碍（50.9％），其次是厌食症（42.6％），胸痛（32.6％），胃炎（32.3％），咳嗽（29.3％），和呼吸困难（29.1％）。急性期症状的平均总得分是31.0±16.3，而COVID 19症状后得分是13.1±12.6（P <0.001）。持续COVID-19后症状的主要决定因素是是否需要氧气治疗（P <0.001），既往高血压（P = 0.039），慢性肺部疾病（P = 0.012）和任何慢性合并症（P = 0.004）。急性发作期间的症状评分与COVID-19后阶段的症状评分之间存在相关性（P <0.001，r = 0.67）。急性期评分的临界点> 18，具有83.5％的敏感性和73.3％的特异性，可预测COVID-19后症状的发生。COVID-19可以表现出广泛的COVID-19后长期症状。急性期症状严重性增加和COVID-19症状评分> 18以及任何合并症均增加了持续发生COVID-19后表现和严重性的风险。