Bisulfite (HSO₃⁻) and sulfite (SO₃²⁻) are involved in numerous physiological processes of living systems. However, high levels of these substances are often correlated to many diseases. Herein, we designed and synthesized a simple full water-soluble colorimetric and far-red fluorescent probe (E)-1-methyl-4-(2-(1-methylquinolin-1-ium-3-yl)vinyl)quinolin-1-ium iodide trifluoromethanesulfonate (DQ) for HSO₃⁻/SO₃²⁻ detection by coupling 1,4-dimethylquinolinium with 3-quinolinium carboxaldehyde for the first time. The probe DQ showed high selectivity for HSO₃⁻ detection via a 1,4-nucleophilic addition reaction with distinct color changes from colorless to purple-red and remarkable far-red fluorescence enhancement in pure aqueous solutions. Specifically, the probe displayed a fast response (<15 s) for bisulfite, which renders it suitable for real time detection of HSO₃⁻. Under the optimized conditions, the far-red fluorescence intensity was linear to the concentrations of HSO₃⁻ in the range from 0 to 25 μM and the detection limit was as low as 0.11 μM. Additionally, the probe could be applied to sense HSO₃⁻ on paper strips, real sample including vermicelli and sugar and image HSO₃⁻ in living cells, which indicated that probe DQ has potential application in food samples and living systems.

亚硫酸氢盐（HSO ₃ ^- ）和亚硫酸盐（SO ₃ ^2-）参与生命系统的许多生理过程。但是，这些物质的高水平通常与许多疾病有关。在这里，我们设计并合成了一个简单的全水溶性比色和远红荧光探针（E）-1-甲基-4-（2-（1-甲基喹啉-1-基-3-基）乙烯基）喹啉-1鎓碘化物酯（DQ）为HSO ₃ ^- / SO ₃ ^2-检测通过偶合1,4- dimethylquinolinium用3-喹啉甲醛首次。探头DQ表现出较高的选择性HSO ₃ ^-检测通过1，4-亲核加成反应，在纯水溶液中具有从无色到紫红色的明显颜色变化，并具有明显的远红色荧光增强。具体地，探针显示亚硫酸氢盐的快速响应（<15秒），这使得它适合于HSO的实时检测₃ ^- 。在优化条件下，远红荧光强度呈线性关系，HSO的浓度₃ ^-在0至25μm范围内，检测限低至0.11μM。此外，探针可应用于感测HSO ₃ ^-上纸条，包括粉条和糖和图像HSO真实样品₃ ^-在活细胞中，这表明探针DQ在食品样本和生命系统中具有潜在的应用。