Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves.

中文翻译：

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伴有和不伴有精神病的双相情感障碍患者的白质微观结构减少

I型双相情感障碍的情感和精神病特征有相当大的重叠，这使得确定其病因和开发靶向治疗的努力变得复杂。为了阐明伴有精神病的双相情感障碍 (BDP) 和无精神病双相情感障碍 (BDNP) 的机制是相似还是不同，必须首先建立这两个群体的神经生物学概况。这项研究检查了 BDP 和 BDNP 组的白质结构，以努力确定双相和健康组之间或双相亚组本身之间可能不同的白质部分。