Curcumin was incorporated into oil/water (o/w) emulsion by dissolving it in soybean oil to cover the surface of the oil droplets with a pH-sensitive polyelectrolyte complex (PEC) composed of chitosan and fucoidan molecules. This curcumin-loading efficiency of the suspension system was investigated. The size and zeta potential distributions of novel curcumin-loaded chitosan nanoparticles self-assembled with fucoidan (CFNPLC) were assessed at various pH and fucoidan-to-chitosan mass ratio (FCMR). The release behavior of curcumin from CFNPLC was confirmed quantitatively by the superimposition of relevant release behavior. The release of curcumin from CFNPLC prepared with a chitosan solution of pH 6 for one to two days was slower than that from CFNPLC prepared with a chitosan solution of pH 3.7 for five to 10 hrs. This was attributed to the higher affinity of a chitosan molecule to curcumin molecules at a higher pH. The centrifugation of release medium accelerated the release of curcumin droplet from the surface of CFNPLC into the release medium much faster than a conventional curcumin release. Not to mention a high stability of curcumin blended with soybean oil, encapsulated in CFNPLC, the advantage of the CFNPLC is addressed in such a way that curcumin releasing period of a conventional curcumin delivery using CFNPLC, is supposed to be extended for much longer time than one to two days of the curcumin release period in this study. Thus, CFNPLC can bring about an enhanced effect of curcumin bioavailability resulting from the high curcumin stability and its extended release because it was dissolved in soybean oil and CFNPLC sustained slow curcumin-release for more than days in the oral drug (curcumin) delivery system. Therefore, CFNPLC can be treated mainly as a food-functional additive or healthy dietary product for tumor patients.

通过将姜黄素溶于大豆油中，以壳聚糖和岩藻依聚糖分子组成的pH敏感的聚电解质复合物（PEC）将姜黄素掺入油/水（o / w）乳液中，以覆盖油滴表面。研究了悬浮系统的姜黄素加载效率。在各种pH和岩藻依聚糖与壳聚糖质量比（FCMR）下，评估了用岩藻依聚糖（CFNPLC）自组装的新型姜黄素负载壳聚糖纳米粒的大小和ζ电位分布。姜黄素从CFNPLC的释放行为已通过相关释放行为的叠加进行了定量证实。姜黄素从用pH 6的壳聚糖溶液制备的CFNPLC释放1至2天比从用pH 3.7的壳聚糖溶液制备的CFNPLC释放5至10小时要慢。这归因于在较高pH下壳聚糖分子对姜黄素分子的较高亲和力。释放介质的离心加速了姜黄素液滴从CFNPLC表面到释放介质的释放，其速度比常规姜黄素释放快得多。更不用说封装在CFNPLC中的姜黄素与大豆油混合的高稳定性，CFNPLC的优势得到了解决，即与使用CFNPLC的常规姜黄素递送相比，姜黄素的释放期应比延长更长的时间。这项研究中姜黄素释放期为一到两天。从而，CFNPLC可以由于姜黄素的高稳定性及其延长的释放而提高姜黄素的生物利用度，因为它溶解在大豆油中，并且CFNPLC在口服药物（姜黄素）递送系统中持续缓慢的姜黄素释放超过几天。因此，CFNPLC可以主要用作食品功能性添加剂或肿瘤患者的健康饮食产品。