Moyamoya disease (MMD) is a cerebrovascular disease that is characterized by progressive stenosis or occlusion of the internal carotid arteries and its main branches, which leads to the formation of abnormal small collateral vessels. However, little is known about how these special vascular structures affect cortical network connectivity and brain function. By applying EEG analysis and graphic network analyses undergoing EEG recording of subjects with eyes-closed (EC) and eyes-open (EO) resting states, and working memory (WM) tasks, we examined the brain network features of hemorrhagic (H_MMD) and ischemic MMD (I_MMD) brains. For the first time, we observed that I_MMD had the much lower alpha-blocking rate during EO state than healthy controls while H_MMD exhibited the relatively low EEG activity rate across all the behavior states. Further, I_MMD showed strong network connections in the alpha-wave band in frontal and parietal regions during EO and WM states. EEG frequency and network topological maps during both resting and WM states indicated that the left frontal lobe and left parietal lobe in H_MMD patients and the right parietal lobe and temporal lobe in I_MMD patients have clear differences compared with controls, which provides a new insight to understand distinct electrophysiological features of MMD. However, due to the small sample size of recruited patient subjects, the result conclusion may be limited.

烟雾病（Moyamoya disease，MMD）是一种以颈内动脉及其主要分支进行性狭窄或闭塞，导致异常小侧支血管形成为特征的脑血管疾病。然而，对于这些特殊的血管结构如何影响皮质网络连接和大脑功能知之甚少。通过应用脑电图分析和图形网络分析，对闭眼 (EC) 和睁眼 (EO) 静息状态和工作记忆 (WM) 任务的受试者进行脑电图记录，我们检查了出血性 (H _MMD )的脑网络特征和缺血性 MMD (I _MMD ) 大脑。我们第一次观察到 I _MMD在 EO 状态下的 α 阻断率比健康对照组低得多，而 H_MMD在所有行为状态下都表现出相对较低的 EEG 活动率。此外，在 EO 和 WM 状态期间，I _MMD在额叶和顶叶区域的 alpha 波段中显示出强大的网络连接。_{静息和 WM 状态下的脑电图频率和网络拓扑图表明，H MMD}患者的左额叶和左顶叶以及 I _MMD患者 的右顶叶和颞叶与对照组相比有明显差异，这提供了新的见解了解MMD的不同电生理特征。然而，由于招募的患者受试者样本量较小，结果结论可能有限。