ABSTRACT Uncontrolled hazardous wastes sites have the potential to adversely impact human health and damage or disrupt ecological systems and the greater environment. Four decades have passed since the Superfund law was enacted, allowing increased exposure time to these potential health hazards while also allowing advancement of analysis techniques. Florida has the sixth highest number of Superfund sites in the US and, in 2016, Florida was projected to have the second largest number of new cancer cases in the US. We explore statewide cancer incidence in Florida from 1986 to 2010 to determine if differences or associations exist in counties containing Superfund sites compared to counties that do not. To investigate potential environmental associations with cancer incidence; results using spatial and nonspatial mixed models were compared. Using a Poisson–Gamma mixture model, our results provide some evidence of an association between cancer incidence rates and Superfund site hazard levels, as well as proxy measures of water contamination around Superfund sites. In addition, results build upon previously observed gender differences in cancer incidence rates and further indicate spatial differences for cancer incidence. Heterogeneity among cancer incidence rates were observed across Florida with some mild association with Superfund exposure proxies.

中文翻译：

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佛罗里达州的超级基金所在地和癌症发病率的潜在关联

摘要不受控制的危险废物场所有可能对人类健康产生不利影响，破坏或破坏生态系统和更广阔的环境。自《超级基金法》颁布以来已经过去了四十年，这使得增加了对这些潜在健康危害的暴露时间，同时也使分析技术得到了发展。佛罗里达州的超级基金站点数量在美国排名第六，并且在2016年，佛罗里达州的新癌症病例数预计在美国排名第二。我们探索了从1986年到2010年在佛罗里达州发生的全州癌症发病率，以确定与拥有超级基金站点的县相比，拥有超级基金站点的县是否存在差异或关联。调查与癌症发生率的潜在环境关联；比较了使用空间和非空间混合模型得出的结果。使用Poisson-Gamma混合模型，我们的结果提供了一些证据，表明癌症的发病率与Superfund站点的危险程度之间存在关联，以及Superfund站点周围水污染的替代度量。另外，结果建立在先前观察到的癌症发病率性别差异上，并进一步表明了癌症发病率的空间差异。在佛罗里达州观察到癌症发病率之间的异质性，与Superfund暴露代理存在一定程度的关联。结果建立在先前观察到的癌症发病率性别差异的基础上，进一步表明了癌症发病率的空间差异。在佛罗里达州观察到癌症发病率之间的异质性，与Superfund暴露代理存在一定程度的关联。结果建立在先前观察到的癌症发病率性别差异的基础之上，并进一步表明了癌症发病率的空间差异。在佛罗里达州观察到癌症发病率之间的异质性，与Superfund暴露代理存在一定程度的关联。