MOFs-Derived Fe–N Codoped Carbon Nanoparticles as O2-Evolving Reactor and ROS Generator for CDT/PDT/PTT Synergistic Treatment of Tumors,Bioconjugate Chemistry

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MOFs-Derived Fe–N Codoped Carbon Nanoparticles as O2-Evolving Reactor and ROS Generator for CDT/PDT/PTT Synergistic Treatment of Tumors
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-02-05 , DOI: 10.1021/acs.bioconjchem.0c00694
Chunxiao Sui _{1,

2} , Rui Tan _{2,

3} , Yiwen Chen _{1,

2} , Guotao Yin _{1,

2} , Ziyang Wang _{1,

2} , Wengui Xu ₁ , Xiaofeng Li ₁

Affiliation

Metal–organic frameworks (MOFs) derivatives had been widely explored in electronic and environmental fields, but rarely evaluated in the biomedical applications. Herein, Fe–N codoped carbon (FeNC) nanoparticles were synthesized and characterized via facile pyrolysis of precursor ZIF-8 (Fe/Zn) nanoparticles, and their potential applications in tumor therapy were assessed in this investigation both in vitro and in vivo. After PAA (sodium polyacrylate) modification, the FeNC@PAA nanoparticles were able to initiate a Fe-based Fenton-like reaction to generate ·OH and O₂ for chemodynamic therapy (CDT) and O₂ evolution. Meanwhile, the porphyrin-like metal center in the FeNC@PAA nanoparticles could be used as a photosensitizer for photodynamic therapy (PDT) of tumors, which could be enhanced by O₂ generated in CDT. Furthermore, the FeNC@PAA nanoparticles were also found to be effective in photothermal therapy (PTT) with a photothermal conversion efficiency of 29.15%, owing to a high absorbance in the near-infrared region (NIR). In conclusion, the synthesized FeNC@PAA nanoparticles exhibited promising applications in O₂ evolution and CDT/PDT/PTT synergistic treatment of tumors.

中文翻译：

MOFs 衍生的 Fe-N 共掺杂碳纳米颗粒作为 O2-Evolving 反应器和 ROS 发生器用于 CDT/PDT/PTT 协同治疗肿瘤

金属有机骨架（MOFs）衍生物在电子和环境领域得到了广泛的探索，但很少在生物医学应用中进行评估。在此，Fe-N 共掺杂碳 (FeNC) 纳米粒子通过前体 ZIF-8 (Fe/Zn) 纳米粒子的轻松热解合成和表征，并在本研究中在体外和体内评估了它们在肿瘤治疗中的潜在应用。PAA（聚丙烯酸钠）改性后，FeNC@PAA纳米颗粒能够引发Fe基类芬顿反应，生成·OH和O ₂用于化学动力学治疗（CDT）和O ₂进化。同时，FeNC@PAA纳米颗粒中的卟啉样金属中心可用作肿瘤光动力疗法（PDT）的光敏剂，可通过CDT中产生的O ₂增强该光敏剂。此外，还发现 FeNC@PAA 纳米粒子在近红外区域 (NIR) 具有高吸光度，因此在光热疗法 (PTT) 中也有效，光热转换效率为 29.15%。总之，合成的FeNC@PAA纳米颗粒在O ₂演化和CDT/PDT/PTT协同治疗肿瘤方面表现出有前景的应用。

更新日期：2021-02-17

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