The purpose of this study is to investigate whether Flattening Filter (FF) and Flattening Filter Free (FFF) beams cause any difference on rat peripheral blood levels in a single dose (SD) and fractioned dose (FD) plans.

Forty Sprague Dawley rats were randomly divided into five groups. No action was taken on the subjects in the control group (Group 1). FF-SD (Group 2) and FF-FD (Group 4) subjects received radiotherapy at 400 MU/min in SD 16 Gy and 5-day consecutive FD 32 Gy, respectively. FFF-SD (Group 3) and FFF-FD (Group 5) subjects received radiotherapy at 1400 MU/min in SD 16 Gy and 5-day consecutive FD 32 Gy, respectively. Blood samples were collected 24 h after radiotherapy. The levels of white blood cells (WBC), granulocytes (GRAN%), red blood cells (RBCs), lymphocytes (LYM%), hemoglobin (HGB) and platelets (PLT) were analyzed.

In SD and FD plans, the levels of hematological parameters except for PLT level due to FF and FFF beams decreased statistically significant when compared with the control group (p < 0.05), but it was observed that the values of these parameters decreased less in the FD plans. In addition, when the effects of FF and FFF beams on peripheral blood cells were compared, a statistically significant difference was observed (p < 0.05).

It was shown that FF and FFF beams significantly decrease hematological parameter levels in SD and FD plans. In addition, it was concluded that FFF beams were more dominant when we compared the effects of FF and FFF beams on peripheral blood cells.

这项研究的目的是调查在单剂量（SD）和分剂量（FD）计划中，展平滤光片（FF）和无展平滤光片（FFF）光束是否对大鼠外周血水平造成任何差异。

将40只Sprague Dawley大鼠随机分为五组。对照组（第1组）未对受试者采取任何措施。FF-SD（第2组）和FF-FD（第4组）受试者分别以400 MU / min的速度在SD 16 Gy和连续5天的FD 32 Gy中接受放射治疗。FFF-SD（第3组）和FFF-FD（第5组）对象分别以1400 MU / min的速度分别在SD 16 Gy和连续5天FD 32 Gy中接受放射治疗。放疗后24小时收集血液样本。分析白细胞（WBC），粒细胞（GRAN％），红细胞（RBC），淋巴细胞（LYM％），血红蛋白（HGB）和血小板（PLT）的水平。

在SD和FD计划中，与FF组相比，FF和FFF束引起的血液学参数水平（PLT水平除外）下降具有统计学意义（p <0.05），但观察到这些参数在血液中的下降幅度较小。 FD计划。此外，当比较FF和FFF光束对外周血细胞的影响时，观察到统计学上的显着差异（p <0.05）。

结果表明，FF和FFF光束显着降低了SD和FD计划中的血液学参数水平。此外，可以得出结论，当我们比较FF和FFF光束对外周血细胞的影响时，FFF光束更占优势。