Cognitive and sensory deficits were considered a core feature of major depressive disorder (MDD). However, few studies investigated stereopsis integrity in patients with MDD. Thus, the objectives of this study investigated stereopsis integrity and its correlations with cognitive function and depressive symptom in patients with MDD. 90 patients with MDD and 116 healthy controls (HCs) were enrolled in this study. Their stereoacuity was evaluated using the Titmus Stereopsis Test as well as assessing their cognitive function and depressive symptom by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Hamilton Depression Scale (HAMD). Log seconds of arc was significantly higher in patients than HCs (1.92 ± 0.41 versus 1.67 ± 0.16, t = 5.35, p < 0.0001). The percentage of patients with correct stereopsis detection was markedly declined in 400 (z = 3.06, p = 0.002), 200 (z = 3.84, p < 0.001), 140 (z = 4.73, p < 0.001), 100 (z = 4.58, p < 0.001), 80 (z = 5.06, p < 0.001), 60 (z = 4.72, p < 0.001), 50 (z = 4.24, p < 0.001), and 40 (z = 4.85, p < 0.001) seconds of arc compared with HCs. Log seconds of arc was significantly correlated with the RBANS total score (r = −0.38, p < 0.0001), subscores of attention (r = −0.49, p < 0.0001) and language (r = −0.33, p = 0.001) rather than HAMD score (r = 0.03, p = 0.78) in MDD patients. In addition, log seconds of arc was significantly related to the RBANS total score (r = −0.58, p < 0.0001) and language score (r = −0.45, p = 0.006) rather than attention score (r = −0.30, p = 0.07) in HCs. Further stepwise multivariate regression analyses showed the negative correlation of log seconds of arc with attention score (β = −0.80, t = −3.95, p < 0.0001) rather than HAMD score (β = −0.008, t = −0.09, p = 0.93) in MDD patients. However, there was no relationship between log seconds of arc and attention score in HCs (β = 1.52, t = 1.19, p = 0.24). Our results identified the marked deficits of stereopsis in MDD patients that were tightly correlated with their attention functioning rather than depressive symptom.

认知和感觉缺陷被认为是重度抑郁症（MDD）的核心特征。然而，很少有研究调查 MDD 患者的立体视觉完整性。因此，本研究的目的是调查立体视觉完整性及其与 MDD 患者认知功能和抑郁症状的相关性。90 名 MDD 患者和 116 名健康对照者 (HC) 参加了这项研究。使用 Titmus Stereopsis 测试评估他们的立体视觉，并通过可重复的神经心理状态评估电池 (RBANS) 和汉密尔顿抑郁量表 (HAMD) 评估他们的认知功能和抑郁症状。患者的对数弧秒数显着高于 HC（1.92 ± 0.41 对 1.67 ± 0.16，t  = 5.35，p < 0.0001)。正确立体视检测的患者百分比在 400 (z = 3.06, p  = 0.002)、200 (z = 3.84, p  < 0.001)、140 (z = 4.73, p < 0.001)、100 (z = 4.58)中显着下降, p < 0.001), 80 (z = 5.06, p < 0.001), 60 (z = 4.72, p < 0.001), 50 (z = 4.24, p < 0.001) 和 40 (z = 4.85, p < 0.001)秒弧与 HC 相比。弧的对数秒与 RBANS 总分 ( r  = -0.38, p  < 0.0001)、注意力子分数 ( r  = -0.49, p < 0.0001) 和语言 ( r  = -0.33, p  = 0.001) 显着相关，而不是HAMD 评分 ( r  = 0.03, p = 0.78) 在 MDD 患者中。此外，弧的对数秒与 RBANS 总分 ( r  = -0.58, p  < 0.0001) 和语言分数 ( r  = -0.45, p  = 0.006) 而非注意力分数 ( r  = -0.30, p  = 0.07) 在 HC 中。进一步的逐步多元回归分析显示弧的对数秒数与注意力得分（β = -0.80，t  = -3.95，p  < 0.0001）而不是 HAMD 得分（β = -0.008，t  = -0.09，p  = 0.93 ）呈负相关) 在 MDD 患者中。然而，在 HC 中，弧的 log 秒数与注意力得分之间没有关系（β = 1.52，t = 1.19，p  = 0.24）。我们的研究结果确定了 MDD 患者立体视觉的显着缺陷，这与他们的注意力功能而非抑郁症状密切相关。