Electrospun membranes and hydrogels are widely used to prevent tendon adhesion. Hydrophobic anti-inflammatory drugs could be fully loaded on the electrospinning membrane through the electrospinning process, which can better prevent tendon adhesion. Basic fibroblast growth factor (bFGF) could promote tendon healing. However, the bioactivity of free bFGF is easily inactivated, therefore, a suitable carrier is needed. As a carrier, hydrogel has little effect on the bioactivity of the protein drugs. In this work, a poly(lactic-co-glycolic) acid (PLGA) electrospun membrane loaded with ibuprofen (IBU) was prepared and named EMI. Additionally, Methoxy poly(ethylene glycol)-block-poly(L-valine) (PEG-PLV) was synthesized. bFGF was added to the PEG-PLV solution, a hydrogel containing bFGF (PLVB) was obtained after gelling. PLVB was applied to the surface of EMI, a double-layer composite membrane named EMI-PLVB was obtained. This membrane was used to prevent Achilles tendon adhesion and promote healing. IBU and bFGF in EMI-PLVB were continuously released in vitro. The inflammatory factors at the tendon healing site were significantly reduced, and the production of type I collagen (Col- I) and type III Collagen (Col-III) at the tendon healing site was also increased in vivo. In conclusion, this double-layer composite membrane drug release system can effectively prevent tendon adhesion and promote tendon healing.

电纺膜和水凝胶广泛用于防止肌腱粘连。疏水性消炎药可以通过静电纺丝过程完全负载在静电纺丝膜上，可以更好地防止肌腱粘连。碱性成纤维细胞生长因子（bFGF）可以促进肌腱愈合。但是，游离bFGF的生物活性容易失活，因此需要合适的载体。作为载体，水凝胶对蛋白质药物的生物活性影响很小。在这项工作中，制备了布洛芬（IBU）负载的聚乳酸-乙醇酸（PLGA）电纺膜，并命名为EMI。另外，合成了甲氧基聚（乙二醇）-嵌段-聚（L-缬氨酸）（PEG-PLV）。将bFGF加入到PEG-PLV溶液中，胶凝后获得含有bFGF（PLVB）的水凝胶。将PLVB涂在EMI的表面，得到双层复合膜EMI-PLVB。该膜用于防止跟腱粘连并促进愈合。EMI-PLVB中的IBU和bFGF在体外持续释放。肌腱愈合部位的炎症因子显着降低，并且在肌腱愈合部位的I型胶原蛋白（Col-I）和III型胶原蛋白（Col-III）的产生也得以体内增加。总之，这种双层复合膜药物释放系统可以有效防止肌腱粘连，促进肌腱愈合。肌腱愈合部位的炎症因子显着降低，并且在肌腱愈合部位的I型胶原蛋白（Col-I）和III型胶原蛋白（Col-III）的产生也得以体内增加。总之，这种双层复合膜药物释放系统可以有效地防止肌腱粘连并促进肌腱愈合。肌腱愈合部位的炎症因子显着降低，并且在肌腱愈合部位的I型胶原蛋白（Col-I）和III型胶原蛋白（Col-III）的产生也得以体内增加。总之，这种双层复合膜药物释放系统可以有效地防止肌腱粘连并促进肌腱愈合。