Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). This CLR identifies ligands independently of Ca²⁺ and is majorly involved in coupling of innate with adaptive immunity. Formerly, Dectin-1 was best known for its role in anti-fungal defense only. However, recent explorations suggested its wider role in defense against variety of infectious diseases caused by pathogens including bacteria, parasites and viruses. In fact, Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders. Being a defensive PRR, Dectin-1 results in optimal immune responses in collaboration with other PRRs, but the overall evaluation reinforces the hypothesis of disease development on dis-regulation of Dectin-1 activity. This underscores the impact of Dectin-1 polymorphisms in modulating protein expression and generation of non-optimal immune responses through defective collaborations, further underlining their therapeutic potential. To add on, Dectin-1 influence autoimmunity and severe inflammation accredited to recognition of self T cells and apoptotic cells through unknown ligands. Few reports have also testified its redundant role in infections, which makes it a complicated molecule to be fully resolved. Thus, Dectin-1 is a hub that runs a complex collaborative network, whose interactive wire connections to different PRRs are still pending to be revealed. Alternatively, so far focus of almost all the researchers was the two major cell surface isoforms of Dectin-1, despite the fact that its soluble functional intracellular isoform (Dectin-1E) has already been dissected but is indefinable. Therefore, this review intensely recommends the need of future research to resolve the un-resolved and treasure the comprehensive role of Dectin-1 in different clinical outcomes, before determining its therapeutic prospective.

树突状细胞相关C型凝集素1（Dectin-1），又称β-葡聚糖受体，是一种新兴的模式识别受体（PRR），属于C型凝集素受体（CLR）家族。^{此 CLR 可独立于 Ca 2+}识别配体主要参与先天免疫与适应性免疫的耦合。以前，Dectin-1 仅以其在抗真菌防御中的作用而闻名。然而，最近的探索表明，它在防御由细菌、寄生虫和病毒等病原体引起的各种传染病方面具有更广泛的作用。事实上，Dectin-1 信号轴已被认为是一种有效的癌症治疗策略。Dectin-1 也已在心脏、呼吸系统、肠道、神经和发育障碍中得到阐明。作为一种防御性 PRR，Dectin-1 与其他 PRR 合作产生最佳免疫反应，但总体评估强化了疾病发展对 Dectin-1 活性失调的假设。这强调了 Dectin-1 多态性通过有缺陷的协作调节蛋白质表达和产生非最佳免疫反应的影响，进一步强调了它们的治疗潜力。此外，Dectin-1 影响自身免疫和严重炎症，这些炎症通过未知配体识别自身 T 细胞和凋亡细胞。很少有报告证明它在感染中的多余作用，这使得它成为一个需要完全解决的复杂分子。因此，Dectin-1 是一个运行复杂协作网络的枢纽，其与不同 PRR 的交互式有线连接仍有待揭示。或者，到目前为止，几乎所有研究人员都关注 Dectin-1 的两种主要细胞表面异构体，尽管它的可溶性功能性细胞内异构体 (Dectin-1E) 已经被解剖但无法确定。因此，本综述强烈建议未来的研究需要在确定其治疗前景之前解决未解决的问题并珍惜 Dectin-1 在不同临床结果中的综合作用。