The local dynamics of fluidized pharmaceutical carrier powders in a turbulent channel flow was studied using particle image velocimetry (PIV) and High-speed, long-distance microscopy (HS-LDM). Four different lactose powders which have been used as a drug carrier in dry powder inhalers were used in this study. These powders have median powder particle diameters ranging between 61 and 121 µm. Air flow velocities ranging between 13.3 m/s and 66.7 m/s were examined. In addition, the effect of grid blockage ratio (ranging from ~25% to ~40% of the area of channel cross-section) was also investigated. Results show that the high-speed, long-distance microscopy (HS-LDM) technique was able to capture the mean velocity of the particles, and the results corresponded well with the PIV measurements. Results from the high-speed, long-distance microscopy (HS-LDM) method also demonstrate that the span of particle velocity closely follows that of the particle size distribution both for cohesive and non-cohesive powders. This study contributes towards an improved understanding of pharmaceutical carrier dynamics in turbulent channel flows and demonstrates how advanced image processing can be used to capture local particle dynamics.

使用粒子图像测速仪 (PIV) 和高速长距离显微镜 (HS-LDM) 研究了湍流通道中流化药物载体粉末的局部动力学。本研究使用了四种不同的乳糖粉末，它们已用作干粉吸入器中的药物载体。这些粉末的中值粉末粒径范围在 61 和 121 µm 之间。检查了介于 13.3 m/s 和 66.7 m/s 之间的气流速度。此外，还研究了网格阻塞率（通道横截面面积的~25％至~40％）的影响。结果表明，高速长距离显微镜（HS-LDM）技术能够捕捉到粒子的平均速度，结果与PIV测量结果吻合良好。高速的结果，长距离显微镜（HS-LDM）方法还表明，粒子速度的跨度与粘性和非粘性粉末的粒度分布密切相关。这项研究有助于提高对湍流通道流中药物载体动力学的理解，并展示了如何使用先进的图像处理来捕获局部粒子动力学。