In a multigenerational study of families at risk for depression, individuals with a lifetime history of depression had: 1) abnormal perceptual asymmetry (PA; smaller left ear/right hemisphere [RH] advantage) in a dichotic emotion recognition task, and 2) reduced RH late positive potential (P3_RH) during an emotional hemifield task. We used standardized difference scores for processing auditory (PA sad-neutral) and visual (P3_RH negative-neutral) stimuli for 112 participants (52 men) in a logistic regression to predict history of depression, anxiety or comorbidity of both. Whereas comorbidity was separately predicted by reduced PA (OR = 0.527, p = .042) or P3_RH (OR = 0.457, p = .013) alone, an interaction between PA and P3_RH (OR = 2.499, p = .011) predicted depressive disorder. Follow-up analyses revealed increased probability of depression at low (lack of emotional differentiation) and high (heightened reactivity to negative stimuli) levels of both predictors. Findings suggest that reduced or heightened right-lateralized emotional responsivity to negative stimuli may be uniquely associated with depression.

在一项针对有抑郁风险的家庭的多代人研究中，有终生抑郁症病史的个体：1）在双歧情绪识别任务中存在异常的感知不对称（PA；较小的左耳/右半球 [RH] 优势），以及 2）减少情绪半场任务期间的RH 晚期正电位 (P3 _{RH )。}我们在逻辑回归中对 112 名参与者（52 名男性）的听觉（PA 悲伤中性）和视觉（P3 _{RH负中性）刺激进行处理，以预测两者的抑郁、焦虑或合并症病史。}而合并症分别通过降低 PA (OR = 0.527, p = .042) 或 P3 _RH (OR = 0.457, p_{= .013) 单独，PA 和 P3 RH}之间的相互作用(OR = 2.499, p = .011) 预测抑郁症。后续分析显示，在两个预测因子的低（缺乏情绪分化）和高（对负面刺激的反应性增强）水平下，抑郁症的可能性增加。研究结果表明，对负面刺激的右侧情绪反应减少或增加可能与抑郁症有关。