The offspring of parents with bipolar disorder (OBD) exhibit elevated rates of psychopathology. However, preventative interventions are lacking. Using a quasi-experimental design with an assessment-only control group, we examined if a 12-week program (entitled Reducing Unwanted Stress in the Home, RUSH) decreases internalizing and externalizing symptoms in the OBD (aged 6–11 years) via intervention-related gains in parent–child interaction quality. Participants consisted of 55 offspring (26 OBD; 29 controls) and their parents. Assessments were conducted at four time points up to six months following the end of the RUSH program, during which parent and teacher ratings of child symptoms, and parent–child interaction quality (parental positivity and negativity, and dyadic mutuality) were measured. Multilevel modelling showed improved parental positivity and negativity, and dyadic mutuality among target dyads immediately and six months post-intervention. For the bootstrapping mediation analyses, intervention-related change in parental negativity fully mediated the relations between having participated in the RUSH program and lower parent-reported internalizing problems among the OBD six months later. These data provide evidence of the efficacy of the RUSH program for OBD who exhibited improved interactions with their parents post-intervention. Further investigation via a randomized controlled trial is warranted.

患有双相情感障碍 (OBD) 的父母的后代表现出更高的精神病理学率。但是，缺乏预防性干预措施。使用带有仅评估对照组的准实验设计，我们检查了为期 12 周的计划（名为减少家中不必要的压力，RUSH）是否通过干预减少 OBD（6-11 岁）的内化和外化症状-亲子互动质量的相关收益。参与者包括 55 个后代（26 个 OBD；29 个对照）和他们的父母。在 RUSH 计划结束后最多六个月的四个时间点进行了评估，在此期间测量了父母和老师对儿童症状的评分以及亲子互动质量（父母的积极性和消极性，以及二元性）。多层次建模显示，父母的积极性和消极性得到改善，并且在干预后立即和六个月内，目标对偶之间的二元相互性有所改善。对于自举中介分析，父母消极情绪的干预相关变化完全调节了参与 RUSH 计划与六个月后 OBD 中较低的父母报告的内化问题之间的关系。这些数据提供了 RUSH 计划对 OBD 的疗效的证据，他们在干预后与父母的互动有所改善。有必要通过随机对照试验进行进一步调查。与干预相关的父母消极情绪的变化完全调节了参与 RUSH 计划与六个月后 OBD 中较低的父母报告的内化问题之间的关系。这些数据提供了 RUSH 计划对 OBD 的疗效的证据，他们在干预后与父母的互动有所改善。有必要通过随机对照试验进行进一步调查。父母消极情绪的干预相关变化完全调节了参与 RUSH 计划与 6 个月后 OBD 中父母报告的内化问题降低之间的关系。这些数据提供了 RUSH 计划对 OBD 的疗效的证据，他们在干预后与父母的互动有所改善。有必要通过随机对照试验进行进一步调查。