Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs (BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs.

中文翻译：

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两种不同细菌裂解物的不同抗病毒特性

口服细菌裂解物 (OBL) 可以降低儿童因病毒和细菌来源而反复呼吸道感染的频率和严重程度。OBL 诱导的早期先天免疫反应已经得到证实，但从未研究和比较不同 OBL 的具体特征。进行了一项研究，以在体外评估两种略有不同的 OBL：OM-85 和 Pulmonarom 对感染鼻病毒 (RV-) 的人支气管上皮细胞 (BEC) 的保护作用。此外，由于免疫细胞是抗病毒防御的关键武器，因此还评估了这些 OBL 在小鼠骨髓衍生 DC (BMDC) 中诱导特定细胞因子产生的能力。尽管不同的 OBL 可能共享一些保护宿主细胞免受病毒感染的机制，在 RV 感染的人类 BEC 和小鼠 BMDC 上观察到一些产品特异性抗菌活性。这些结果与可能由 OBL 中包含的不同病原体相关分子模式 (PAMP) 触发的产品特异性反应一致。