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How can we interpret SARS-CoV-2 antibody test results?
Pathogens and Disease ( IF 2.7 ) Pub Date : 2021-01-29 , DOI: 10.1093/femspd/ftaa069
Sofie Føns 1 , Karen A Krogfelt 1
Affiliation  

ABSTRACT
Since the outbreak of COVID-19, the world has raced to understand and accurately diagnose infection caused by SARS-CoV-2. Today, hundreds of commercial antibody tests are on the market despite often lacking proper validation and with unsatisfactory sensitivity and/or specificity. In addition, many questions related to the humoral response remain unresolved, although research is carried out at an unprecedented speed. Despite the shortcomings, serological assays have an important part to play in combating the pandemic by aiding in diagnosis and sero-epidemiological studies. However, careful attention must be paid to the application of serology and the interpretation of serological data—especially in low prevalence regions, both at an individual and at a population level. In this article, we argue that serological results are often misinterpreted, and in the eagerness to be first, methodological rigor is often taking a backseat.


中文翻译:

我们如何解释SARS-CoV-2抗体检测结果?

摘要
自COVID-19爆发以来,全世界都在竞相了解和准确诊断由SARS-CoV-2引起的感染。如今,市场上有数百种商业抗体测试,尽管它们通常缺乏适当的验证并且灵敏度和/或特异性不令人满意。此外,尽管研究以前所未有的速度进行,但许多与体液反应有关的问题仍未解决。尽管存在缺陷,但血清学检测仍可通过协助诊断和血清流行病学研究在对抗大流行中发挥重要作用。但是,必须特别注意血清学的应用和血清学数据的解释,尤其是在个体和人群水平较低的流行地区。在本文中,我们认为血清学结果经常被误解,
更新日期:2021-02-07
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