How and Why to Investigate Multicomponent Reactions Mechanisms? A Critical Review,The Chemical Record

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How and Why to Investigate Multicomponent Reactions Mechanisms? A Critical Review
The Chemical Record ( IF 7.0 ) Pub Date : 2021-02-04 , DOI: 10.1002/tcr.202000165
Marcelo O Rodrigues _{1,

2} , Marcos N Eberlin ₃ , Brenno A D Neto ₁

Affiliation

We review the most innovative efforts and greatest challenges faced when elucidating multicomponent reactions (MCRs) mechanisms. When compared to traditional reactions, the often two or more concurrent reactions pathways and the greater number of possible intermediates in MCRs turn their mechanistic investigation both a harder and trickier task. The common approaches used to investigate reaction mechanisms are often unable to clarify MCRs mechanisms; hence few but clever approaches are currently used to determine these mechanisms and to depict their key transformations. Their complexity has required most innovative approaches and the use of a number of unique techniques that have shed light over the favored pathway selected from the myriad of alternatives theoretically available for MCRs. This review focuses on the most successful efforts applied by a few leading groups to perform these puzzlingly investigations.

中文翻译：

如何以及为什么要研究多组分反应机制？批判性评论

我们回顾了在阐明多组分反应 (MCR) 机制时所面临的最具创新性的努力和面临的最大挑战。与传统反应相比，MCR 中通常有两个或多个并发反应途径和更多可能的中间体使他们的机理研究变得更加困难和棘手。用于研究反应机制的常用方法往往无法阐明 MCR 机制；因此，目前很少使用但聪明的方法来确定这些机制并描述它们的关键转换。它们的复杂性需要最创新的方法和许多独特的技术的使用，这些技术已经阐明了从理论上可用于 MCR 的无数替代方案中选择的有利途径。

更新日期：2021-02-04

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