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Differential optical absorption spectroscopy-based refractive index sensor for cancer cell detection
Optical Review ( IF 1.1 ) Pub Date : 2021-02-03 , DOI: 10.1007/s10043-021-00644-w
Tarunnum Parvin , Kawsar Ahmed , Aadel M. Alatwi , Ahmed Nabih Zaki Rashed

A novel spectroscopic optical sensor is presented for cancerous cell detection in various parts of the human body (i.e., cervix, adrenal gland, breast, skin, and blood). An optimized structure based on compact cladding is successfully designed with enhanced sensitivity and very low confinement loss. The parameters like effective area (Aeff), V-parameter (Veff), spot size (Weff), numerical aperture (NA), and beam quality factor are investigated over the wavelength region 1.4–2.5 µm. The consummation of relative sensitivity is also calculated and is superior to other previous work. The numerical investigation indicates that cancerous cells have higher sensitivity than normal cells. The values investigated for the sensitivity of cervical cancer, adrenal gland cancer, skin cancer, blood cancer, and breast cancer of type I and type II are 94.96%, 95.15%, 94.13%, 94.84%, 95.40%, and 95.51% in X-polarization, respectively, which are higher than the calculated values from any prior works. The explored structure is monomode PCF, with silica as a dielectric material. The finite element method (FEM) has been implemented for investigating the numerical values, implemented on COMSOL Multiphysics (version 5.3). The simple design ensures easy fabrication with ongoing techniques.



中文翻译:

基于差动吸收光谱的折射率传感器用于癌细胞检测

提出了一种新颖的光谱光学传感器,用于检测人体各个部位(子宫颈,肾上腺,乳房,皮肤和血液)中的癌细胞。成功设计出了基于紧凑覆层的优化结构,具有增强的灵敏度和非常低的限制损耗。有效面积(A eff),V参数(V eff),光斑大小(W eff)等参数),数值孔径(NA)和光束质量因数在1.4–2.5 µm的波长区域内进行了研究。相对灵敏度的总和也被计算出来,并且优于其他先前的工作。数值研究表明癌细胞比正常细胞具有更高的敏感性。在X中对I型和II型子宫颈癌,肾上腺癌,皮肤癌,血液癌和乳腺癌的敏感性进行调查的值分别为94.96%,95.15%,94.13%,94.84%,95.40%和95.51%-极化,分别高于任何先前工作的计算值。探索的结构是单模PCF,以二氧化硅为介电材料。在COMSOL Multiphysics(版本5.3)上实现了用于调查数值的有限元方法(FEM)。简单的设计可确保使用持续的技术轻松制造。

更新日期:2021-02-04
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