The review summarizes advances in the development of low-molecular-weight ligands for G-quadruplex (G4) nucleic acid structures published in the past five years. Main chemical classes of these ligands (polyaromatic compounds, macrocyclic systems, metal complexes and heterocyclic derivatives) are considered. The chemical structures of the ligands and their influence on the stabilization of quadruplexes are analyzed. Future prospects of design of G4 ligands and their applications are discussed.

The bibliography includes 188 references.

中文翻译：

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G-四链体核酸的配体

该综述总结了过去五年发表的 G-四链体 (G4) 核酸结构低分子量配体的开发进展。考虑了这些配体的主要化学类别（多环芳烃化合物、大环系统、金属络合物和杂环衍生物）。分析了配体的化学结构及其对四链体稳定性的影响。讨论了G4配体设计及其应用的未来前景。

参考书目包括 188 篇参考文献。