Sixteen new sesquiterpene lactones (1–16) along with 13 known analogues (17–29) were isolated from the whole plants of Centipeda minima. The structures of 1–16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23–26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC₅₀ values of 0.8–2.6, 0.4–3.3, and 1.1–2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC₅₀ values ranging from 0.1 to 0.2 μM.

中文翻译：

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来自蜈蚣全株的细胞毒性和抗炎倍半萜

十六新倍半萜内酯（1 - 16）13个的已知类似物（沿17 - 29）从全植物中分离鹅不食草。的结构1 - 16通过的NMR光谱实验，HRESIMS，单晶X射线衍射分析，以及ECD光谱的组合描绘。化合物23 – 26对 Hela、HCT-116 和 HepG2 细胞显示出有效的细胞毒性，IC ₅₀值分别为 0.8–2.6、0.4–3.3 和 1.1–2.6 μM。化合物8，15，和24对脂多糖激活的 RAW 264.7 小鼠巨噬细胞系中一氧化氮的产生表现出显着的抑制活性，IC ₅₀值范围为 0.1 至 0.2 μM。