This study aimed to identify features of breast intraductal lesions in photoacoustic/ultrasound (PA/US) imaging and compare PA/US with color Doppler flow/ultrasound (CDFI/US) in the evaluation of breast intraductal lesions. In the nine patients with 10 breast intraductal lesions and 8 patients with 8 benign lesions, total vessel scores evaluated from PA/US are significantly greater than those from CDFI/US (p=0.005). PA internal vessel scores and oxygen saturation (SO₂) score are significantly increased in breast intraductal lesions than in benign lesions (p=0.016, p=0.006). With a cutoff PA score (sum of PA internal vessel score and SO₂ score) of 2.5, we obtained a sensitivity of 90% and a specificity of 87.5% in differentiation of two groups. PA/US upgraded 40% of breast intraductal lesions, and downgraded 50% of benign lesions from the Breast Imaging Reporting and Data System grading results based on CDFI/US. PA/US functional imaging has the potential in differentiating breast intraductal lesions.

中文翻译：

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用于评估乳腺导管内病变的功能性光声/超声成像：初步临床发现


本研究旨在确定光声/超声 (PA/US) 成像中乳腺导管内病变的特征，并将 PA/US 与彩色多普勒血流/超声 (CDFI/US) 评估乳腺导管内病变的效果进行比较。在 9 名患有 10 个乳腺导管内病变的患者和 8 名患有 8 个良性病变的患者中，PA/US 评估的总血管评分显着高于 CDFI/US 评估的总血管评分 (p=0.005)。乳腺导管内病变中PA内血管评分和氧饱和度(SO ₂ )评分显着高于良性病变(p=0.016，p=0.006)。当 PA 评分（PA 内血管评分与 SO ₂评分之和）为 2.5 时，我们在区分两组时获得了 90% 的敏感性和 87.5% 的特异性。根据 CDFI/US 的乳腺影像报告和数据系统分级结果，PA/US 升级了 40% 的乳腺导管内病变，降级了 50% 的良性病变。 PA/US 功能成像具有鉴别乳腺导管内病变的潜力。