Glucose and lipids are important nutrients that provide the majority of energy for each organ to maintain homeostasis of the body. With the continuous improvement in living standards, the incidence of metabolic disorder-associated diseases, such as diabetes, hyperlipidemia, and atherosclerosis, is increasing worldwide. Among them, diabetes, which could be induced by both glucose and lipid metabolic disorders, is one of the five diseases with the highest incidence and mortality worldwide. However, the detailed molecular mechanisms underlying glucose and lipid metabolism disorders and target-organ damage are still not fully defined. MicroRNAs (miRNAs) are small, non-coding, single-stranded RNAs, which usually affect their target mRNAs in the cytoplasm by post-transcriptional regulation. Previously, we have found that miR-320 contributed to glucose and lipid metabolism via different signaling pathways. Most importantly, we identified that nuclear miR-320 mediated diabetes-induced cardiac dysfunction by activating the transcription of fatty acid metabolic genes to cause lipotoxicity in the heart. Here, we reviewed the roles of miR-320 in glucose and lipid metabolism and target-organ damage.

中文翻译：

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miR-320在糖脂代谢紊乱相关疾病中的作用


葡萄糖和脂质是重要的营养素，为每个器官提供大部分能量以维持身体的稳态。随着生活水平的不断提高，全球范围内糖尿病、高脂血症、动脉粥样硬化等代谢紊乱相关疾病的发病率不断增加。其中，糖尿病是由糖脂代谢紊乱引起的，是全球发病率和死亡率最高的五种疾病之一。然而，糖脂代谢紊乱和靶器官损伤的详细分子机制尚未完全明确。 MicroRNA (miRNA) 是小型非编码单链 RNA，通常通过转录后调控影响细胞质中的靶标 mRNA。此前，我们发现miR-320通过不同的信号通路促进葡萄糖和脂质代谢。最重要的是，我们发现核 miR-320 通过激活脂肪酸代谢基因的转录来介导糖尿病引起的心脏功能障碍，从而引起心脏的脂毒性。在这里，我们回顾了 miR-320 在糖脂代谢和靶器官损伤中的作用。