Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What's more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition.

中文翻译：

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前列腺癌中环状 RNA 的进展和特性：一个新兴且引人注目的发现前沿

前列腺癌 (PC) 是全球男性中最常见的癌症，占癌症相关死亡的主要原因的 26%。然而，理想和有效的分子标记仍然难以捉摸。CircRNA 最初于 1979 年在植物感染病毒和仙台病毒中观察到，由前 mRNA 反向剪接产生，并通过充分表达发挥作用。与对照相比，前列腺组织中的差异表达揭示了在调节包括致癌和转移在内的过程中的有希望的能力。然而，PC中调控网络的生物学机制需要系统总结。在这篇综述中，我们对circRNAs影响肿瘤进展和转移的确切机制的综合研究提供了启发。更重要的是，我们验证了 circRNA 作为诊断和预后生物标志物的潜在临床应用。circRNAs 的讨论和分析将拓宽我们对 PC 发病机制的认识，并进一步优化当前针对不同疾病的治疗方法。