Lung cancer metastasis is the leading cause of poor prognosis and death for patients. Long noncoding RNAs (lncRNAs) have been validated the close correlation with lung cancer metastasis, but few comprehensive analyses have reported the specific association between lncRNA and cancer metastasis, especially via both competing endogenous RNA (ceRNA) regulatory relationships and functional regulatory networks. Here, we constructed primary and metastatic ceRNA networks, identified 12 and 3 candidate lncRNAs for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) respectively and excavated some drugs that might have potential therapeutic effects on lung cancer progression. In summary, this study systematically analyzed the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided a new idea for screening potential therapeutic drugs for lung cancer.

肺癌转移是患者预后不良和死亡的主要原因。长非编码RNA（lncRNA）已被证实与肺癌转移密切相关，但很少有综合分析报道lncRNA与癌症转移之间的特定关联，特别是通过竞争性内源RNA（ceRNA）调控关系和功能调控网络。在这里，我们构建了主要的和转移性的ceRNA网络，分别确定了12个和3个候选lncRNA用于肺腺癌（LUAD）和肺鳞状细胞癌（LUSC），并挖掘了一些可能对肺癌进展具有潜在治疗作用的药物。综上所述，本研究系统地分析了反复失调的lncRNA在肺癌发生，转移中的竞争关系和调控机制，为筛选潜在的肺癌治疗药物提供了新思路。