Recent studies have attempted to measure several biomarkers to understand the complex interactions of the anatomic systems that may be involved in autism spectrum disorder (ASD). In CNS, galanin takes part in a variety of pathological and physiological processes. Prior research has indicated it is involved in several neuropsychiatric disorders and has a role in inhibiting the neuronal firing and release of serotonin, norepinephrine, and acetylcholine. To date, serum galanin levels have not been investigated in the context of ASD. This study aimed, therefore, to compare the serum galanin levels of children with ASD and healthy controls and to reveal any association between galanin level and the severity of ASD, as well as other psychological and demographic parameters. Serum galanin levels were measured by radioimmunoassay in 116 children with ASD and 98 healthy children. We observed significantly increased serum concentrations of galanin in children with ASD relative to healthy children. Moreover, children with severe ASD had significantly higher galanin levels than those with less severe disease. We also confirmed significant positive correlations between galanin and psychiatric parameters in children with ASD. For the first time, we suggest a possible correlation between serum galanin and the degree of ASD severity. Increased galanin levels may play a role in the pathogenesis of ASD.

最近的研究试图测量几种生物标志物，以了解可能与自闭症谱系障碍 (ASD) 相关的解剖系统的复杂相互作用。在 CNS 中，甘丙肽参与多种病理和生理过程。先前的研究表明，它与几种神经精神疾病有关，并在抑制神经元放电和血清素、去甲肾上腺素和乙酰胆碱的释放方面发挥作用。迄今为止，尚未在 ASD 的背景下研究血清甘丙肽水平。因此，本研究旨在比较 ASD 儿童和健康对照组的血清甘丙肽水平，并揭示甘丙肽水平与 ASD 严重程度以及其他心理和人口统计参数之间的任何关联。通过放射免疫测定法测量了 116 名 ASD 儿童和 98 名健康儿童的血清甘丙肽水平。我们观察到 ASD 儿童相对于健康儿童的血清甘丙肽浓度显着增加。此外，患有严重 ASD 的儿童的甘丙肽水平显着高于病情较轻的儿童。我们还证实了甘丙肽与 ASD 儿童的精神参数之间存在显着的正相关。我们首次提出血清甘丙肽与 ASD 严重程度之间可能存在相关性。甘丙肽水平升高可能在 ASD 的发病机制中起作用。患有严重 ASD 的儿童的甘丙肽水平显着高于病情较轻的儿童。我们还证实了甘丙肽与 ASD 儿童的精神参数之间存在显着的正相关。我们首次提出血清甘丙肽与 ASD 严重程度之间可能存在相关性。甘丙肽水平升高可能在 ASD 的发病机制中起作用。患有严重 ASD 的儿童的甘丙肽水平显着高于病情较轻的儿童。我们还证实了甘丙肽与 ASD 儿童的精神参数之间存在显着的正相关。我们首次提出血清甘丙肽与 ASD 严重程度之间可能存在相关性。甘丙肽水平升高可能在 ASD 的发病机制中起作用。