Abstract

Objective

This study, for the first time, investigates the effect of gum acacia (GA) on the expression of miR-33 and miR-155 and its association with the obesity and inflammation induced by Western diet (WD) consumption in mice.

Methods

Animals were divided into: normal diet (ND) group, WD group, GA group and GA + WD group.

Results

The WD group exhibited higher total body, liver, visceral fat weights, blood total cholesterol, triglycerides and glucose levels compared to ND group. The liver tissues showed severe inflammation and degeneration with higher hepatic TNF-α level. Interestingly, GA + WD group showed a decrease in the biochemical parameters and hepatic TNF-α level but had no effect on the weight increase. It also showed a significant upregulation of miR-33 and miR-155 compared to WD group.

Conclusions

GA mitigated the hyperlipidaemia and inflammation but not weight increase induced by WD ingestion via upregulation of miR-33 and miR-155 while reducing TNF-α level.

中文翻译：

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阿拉伯树胶对miR-33和miR-155的上调可减轻高脂血症和炎症，但不会减轻西方饮食对小鼠的体重增加

摘要

目的

这项研究首次研究了阿拉伯树胶（GA）对miR-33和miR-155表达的影响及其与小鼠西方饮食（WD）摄入引起的肥胖和炎症的关系。

方法

将动物分为：正常饮食（ND）组，WD组，GA组和GA + WD组。

结果

与ND组相比，WD组的人体，肝脏，内脏脂肪重量，血液总胆固醇，甘油三酸酯和葡萄糖水平更高。肝组织显示出严重的炎症和变性，肝TNF-α水平更高。有趣的是，GA + WD组的生化指标和肝TNF-α水平降低，但对体重增加没有影响。与WD组相比，它还显示了miR-33和miR-155的显着上调。

结论

GA可减轻miR-33和miR-155的上调，同时降低TNF-α的水平，从而减轻WD摄入引起的高脂血症和炎症，但不能减轻体重增加。