The formation of memories that contain information about the specific time and place of acquisition, which are commonly referred to as "autobiographical" or "episodic" memories, critically relies on the hippocampus and on a series of interconnected structures located in the medial temporal lobe of the mammalian brain. The observation that adults retain very few of these memories from the first years of their life has fueled a long-standing debate on whether infants can make the types of memories that in adults are processed by the hippocampus-dependent memory system, and whether the hippocampus is involved in learning and memory processes early in life. Recent evidence shows that, even at a time when its circuitry is not yet mature, the infant hippocampus is able to produce long-lasting memories. However, the ability to acquire and store such memories relies on molecular pathways and network-based activity dynamics different from the adult system, which mature with age. The mechanisms underlying the formation of hippocampus-dependent memories during infancy, and the role that experience exerts in promoting the maturation of the hippocampus-dependent memory system, remain to be understood. In this review, we discuss recent advances in our understanding of the ontogeny and the biological correlates of hippocampus-dependent memories.

包含有关特定时间和地点信息的记忆的形成，通常被称为“自传”或“情节”记忆，严重依赖于海马体和位于内侧颞叶的一系列相互连接的结构。哺乳动物的大脑。成年人在他们生命的最初几年几乎保留了这些记忆的观察结果引发了一场长期的争论，即婴儿是否可以产生由依赖海马体的记忆系统处理的成人记忆类型，以及海马体是否参与生命早期的学习和记忆过程。最近的证据表明，即使在其电路尚未成熟的时候，婴儿海马体也能够产生持久的记忆。然而，获取和存储这些记忆的能力依赖于分子通路和基于网络的活动动态，这与成人系统不同，成人系统随着年龄的增长而成熟。婴儿期海马体依赖性记忆形成的潜在机制，以及经验在促进海马体依赖性记忆系统成熟方面的作用仍有待了解。在这篇综述中，我们讨论了我们对海马依赖性记忆的个体发育和生物学相关性的理解的最新进展。经验在促进海马依赖性记忆系统成熟方面的作用仍有待了解。在这篇综述中，我们讨论了我们对海马依赖性记忆的个体发育和生物学相关性的理解的最新进展。经验在促进海马依赖性记忆系统成熟方面的作用仍有待了解。在这篇综述中，我们讨论了我们对海马依赖性记忆的个体发育和生物学相关性的理解的最新进展。