In article number 2000056 Ting‐Yuan Tu and co‐workers demonstrate a facile and highly reproducible laser‐ablated micro U‐well with optimal array arrangement. Cell‐loss free formation of multicellular tumor spheroids is performed in 96‐well plates for high‐throughput drug screening of cisplatin. Dose‐response assays are investigated on T24, A549, and Huh‐7 in both 2D and multicellular tumor spheroid (MCTS) conditions. The permeability dynamics of each type of MCTS are examined.

中文翻译：

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高度可重复的微型U孔阵列板，可促进高通量肿瘤球体培养和药物评估（全球挑战2/2021）

在2000056号文章中，涂婷圆及其同事演示了一种简便且可重复性高的激光烧蚀微型U型孔，具有最佳的阵列布置。多细胞肿瘤球体的无细胞损失形成在96孔板中进行，以进行顺铂的高通量药物筛选。在2D和多细胞肿瘤球体（MCTS）条件下，在T24，A549和Huh-7上研究了剂量反应测定。检查每种类型的MCTS的渗透率动力学。