Associations between alcohol and the places it is consumed are important at all stages of alcohol abuse and addiction. However, it is not clear how the associations are formed in humans or how they influence drinking, and there are few effective strategies to prevent their pathological effects on alcohol use. We used a human laboratory model to study the effects of alcohol environments on alcohol consumption. Healthy regular binge drinkers completed conditioned place preference (CPP) with 0 vs. 80 mg/100 mL alcohol (Paired Group). Control participants (Unpaired Group) completed sessions without explicit alcohol-room pairings. After conditioning, participants completed alcohol self-administration in either the alcohol- or no alcohol-paired room. Paired group participants reported greater subjective stimulation and euphoria, and consumed more alcohol in the alcohol-paired room in comparison to the no alcohol-paired room, and controls tested in either room. Moreover, the strength of conditioning significantly predicted drinking; participants who exhibited the strongest CPP consumed the most alcohol in the alcohol-paired room. This is the first empirical evidence that laboratory-conditioned alcohol environments directly influence drinking. The results also confirm the viability of the model to examine the mechanisms by which alcohol environments stimulate drinking and to test strategies to counteract their influence on behavior.

在酗酒和成瘾的所有阶段，酒精与消费场所之间的关联都很重要。但是，尚不清楚这些联想如何在人类中形成或如何影响饮酒，并且几乎没有有效的策略来防止它们对饮酒的病理影响。我们使用了人类实验室模型来研究酒精环境对酒精消耗的影响。健康的普通暴饮酒者使用0对80 mg / 100 mL酒精（配对组）完成了条件场所偏爱（CPP）。对照参与者（未配对的小组）在没有明确的酒精室配对的情况下完成了会话。调理后，参与者可以在酒精配对室或无酒精配对室中完成酒精自我管理。配对的参与者报告说主观刺激和欣快感增强，并且与没有酒精配对的房间相比，在酒精配对的房间中消耗的酒精更多，并且在任一房间进行了对照测试。此外，调节的强度显着预测了饮酒；表现出最高CPP的参与者在酒精配对室中消耗的酒精最多。这是实验室条件下的酒精环境直接影响饮酒的第一个经验证据。结果还证实了该模型的可行性，该模型可检查酒精环境刺激饮酒的机制，并测试抵消其对行为影响的策略。表现出最高CPP的参与者在酒精配对室中消耗的酒精最多。这是实验室条件下的酒精环境直接影响饮酒的第一个经验证据。结果还证实了该模型的可行性，该模型可检查酒精环境刺激饮酒的机制，并测试抵消其对行为影响的策略。表现出最高CPP的参与者在酒精配对室中消耗的酒精最多。这是实验室条件下的酒精环境直接影响饮酒的第一个经验证据。结果还证实了该模型的可行性，该模型可检查酒精环境刺激饮酒的机制，并测试抵消其对行为影响的策略。