Objective

To assess the therapeutic effect of platelet-rich plasma (PRP) for moderate-to-severe carpal tunnel syndrome (CTS).

Design

A prospective, randomized, double-blinded, controlled trial (1-year follow-up).

Setting

Outpatient of local medical center settings.

Participants

Patients (N=26) who were diagnosed with bilateral moderate-to-severe CTS (total 52 wrists) were included. For each patient, one wrist was randomized into either the PRP or control group and the contralateral wrist of the same patient was allocated to another group.

Twenty-four patients were included in the final data analysis.

Interventions

The wrists in the PRP group received a single ultrasound-guided dose of PRP injection (3.5mL), and the control group received a single ultrasound-guided injection with normal saline (3.5mL).

Main Outcome Measures

The Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) scores were used as the primary outcome. Secondary outcomes encompassed the cross-sectional area of the median nerve and electrophysiological study. Assessments were conducted prior to injection and 1, 3, 6, and 12 months postinjection.

Results

Compared to the control group, the PRP group exhibited significant improvements in BCTQ severity scores at all time points, BCTQ functional scores at the sixth month, and cross-sectional area at the 12th month postinjection (P<.0125).

Conclusions

A single dose of ultrasound-guided perineural PRP injection can provide therapeutic effect for 1 year postinjection.

中文翻译：

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富含血小板血浆对中度至重度腕管综合征的一年疗效：一项前瞻性，随机，双盲，对照试验

客观的

评估富含血小板血浆（PRP）对中度至重度腕管综合症（CTS）的治疗效果。

设计

一项前瞻性，随机，双盲，对照试验（1年随访）。

环境

门诊当地医疗中心的设置。

参加者

包括被诊断患有双侧中度至重度CTS（总共52腕）的患者（N = 26）。对于每位患者，将一只手腕随机分为PRP组或对照组，并将同一位患者的对侧手腕分配给另一组。

最终数据分析包括二十四名患者。

干预措施

PRP组的手腕接受单次超声引导下的PRP注射（3.5mL），对照组接受单次超声引导下的生理盐水（3.5mL）注射。

主要观察指标

波士顿腕隧道综合症问卷（BCTQ）得分被用作主要结局。次要结果包括正中神经的横截面积和电生理研究。在注射前和注射后1、3、6和12个月进行评估。

结果

与对照组相比，PRP组在所有时间点的BCTQ严重性评分，注射后第六个月的BCTQ功能评分和注射后第12个月的横截面积均显示出显着改善（P <.0125）。

结论

单剂量超声引导的会阴神经PRP注射可以在注射后1年内提供治疗效果。