A prodrome is a premonitory set of signs and symptoms indicating the onset of a disease. Prodromes are frequently reported by hereditary angioedema (HAE) patients, antedating attacks by a few hours or even longer. In some studies, high incidence of prodromes was reported by patients, with considerable number being able to predict oncoming attacks. Regrettably, prodromes have never received a consensual definition and have not been properly investigated in a systematic fashion. Therefore, their nature remains elusive and their contribution to the diagnosis and treatment of disorders is uncertain. The term “prodrome,” as used in various pathologies, denotes different meanings, timing, and duration, so it may not be equally suitable for all clinical situations. Perception of a prodrome is unique for each individual patient depending on self-experience. As modern drugs delegate the administration decision to the patients, early detection of a developing attack may help mitigate its severity and allow deployment of appropriate therapy. New diagnostic instruments were recently developed that can assist in defining the attributes of prodromes and their association with attacks. We will review the prodrome phenomenon as exhibited in certain clinical situations, with an emphasis on prodromes of HAE.

前驱症状是一组预示疾病发作的征兆和症状。遗传性血管性水肿 (HAE) 患者经常报告前驱症状，在发作前几个小时甚至更长时间。在一些研究中，患者报告前驱症状的发生率很高，相当多的人能够预测即将到来的发作。遗憾的是，前驱症状从未得到一致同意的定义，也没有以系统的方式进行适当的调查。因此，它们的性质仍然难以捉摸，它们对疾病诊断和治疗的贡献尚不确定。在各种病理中使用的术语“前驱症状”表示不同的含义、时间和持续时间，因此它可能并不同样适用于所有临床情况。根据自身经验，每个患者对前驱症状的感知都是独一无二的。由于现代药物将管理决策委托给患者，因此早期检测发展中的发作可能有助于减轻其严重性并允许部署适当的治疗。最近开发了新的诊断工具，可以帮助定义前驱症状的属性及其与攻击的关联。我们将回顾在某些临床情况下表现出的前驱症状，重点是 HAE 的前驱症状。最近开发了新的诊断工具，可以帮助定义前驱症状的属性及其与攻击的关联。我们将回顾在某些临床情况下表现出的前驱症状，重点是 HAE 的前驱症状。最近开发了新的诊断工具，可以帮助定义前驱症状的属性及其与攻击的关联。我们将回顾在某些临床情况下表现出的前驱症状，重点是 HAE 的前驱症状。