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A Combination of Exercise and Therapy with Cabergoline Attenuate Disturbances of Pituitary-Gonadal Hormones in Hyperprolactinemic Male Patients
Montenegrin Journal of Sports Science and Medicine ( IF 1.3 ) Pub Date : 2020-09-01 , DOI: 10.26773/mjssm.200906
Mohammad Fayiz AbuMoh'd , , Samir Qasim , Nesreen Bataineh , Loay Salman , , ,

This study aimed to investigate whether cabergoline therapy alone for six months or in combination with a light exercise programme for an additional three months can attenuate hyperprolactinemia in 13 male patients (range: 22 to 45 yrs.) through measuring pituitary-gonadal hormones including prolactin, follicle-stimulating hormone, luteinizing hormone, and total testosterone. The exercise programme consisted of walking, brisk walking, jogging, and running for three months, during which the intensity and duration of exercise were gradually increased. All the patients performed the exercise programme at 6.30 AM to exclude the effects of the circadian rhythm. The exercise programme was performed at an intensity below 160 beats per min to ensure filling of the heart with blood during ventricular diastole. Blood samples were collected from each patient on three occasions: before treatment, at the end of cabergoline therapy, and after the combination of light exercise and cabergoline. At the end of cabergoline therapy, descriptive data revealed that serum prolactin levels were decreased while the other hormones were increased but without returning to the normal range, except for one patient. However, at the end of the combination procedure, most hormones, namely prolactin and testosterone, were returned to the normal range in most patients. In conclusion, light exercise combined with cabergoline therapy for additional 3 months after 6 months of cabergoline therapy alone returned hormones in most patients to normal range probably due to improved mood and decreased hostility as a result of tuberoinfundibular pathway activity.

中文翻译:

运动疗法与卡麦角林联合治疗可减轻男性高泌乳素血症患者垂体-性腺激素的干扰

这项研究旨在调查通过评估垂体-性腺激素(包括催乳素),单独使用卡麦角林六个月或结合轻度运动计划再使用三个月可以减轻13名男性患者(22至45岁)的高泌乳素血症,促卵泡激素,促黄体激素和总睾丸激素。运动方案包括步行,快走,慢跑和跑步三个月,在此期间,运动强度和持续时间逐渐增加。所有患者均在6.30 AM进行了锻炼计划,以排除昼夜节律的影响。运动程序以每分钟160次以下的强度执行,以确保在心室舒张期心脏充满血液。在三种情况下分别从每位患者中采集血液样本:治疗之前,卡麦角林治疗结束时以及轻度运动和卡麦角林组合后。卡麦角林治疗结束时,描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素增加,但未恢复正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。在治疗前,卡麦角林治疗结束时以及轻度运动和卡麦角林联合治疗后。卡麦角林治疗结束时,描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素增加,但未恢复正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。在治疗前,卡麦角林治疗结束时以及轻度运动和卡麦角林联合治疗后。卡麦角林治疗结束时,描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素增加,但未恢复正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。轻度运动和卡麦角林结合后。卡麦角林治疗结束时,描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素增加,但未恢复正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。轻度运动和卡麦角林结合后。卡麦角林治疗结束时,描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素增加,但未恢复正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素升高,但未恢复到正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。描述性数据显示,除一名患者外,血清催乳素水平降低,而其他激素升高,但未恢复到正常范围。但是,在合并过程结束时,大多数患者的大多数激素(即催乳激素和睾丸激素)恢复到正常范围。总之,仅进行卡麦角林治疗6个月后,轻度运动加卡麦角林治疗另外3个月即可使大多数患者的激素恢复到正常范围,这可能是由于改善了的肺部和肺小管下通路的活动所致的敌意。
更新日期:2020-09-01
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