Background. The determination of the genetic endowment of athletic performance in sports is an important step in developing personal training sessions or nutritional supplements for success in sports. Information about the genetic parameters responsible for these metabolisms will help sport’s scientist to develop new insights for better performance. Muscle metabolism is one of the key points in better personal athletic performance. Objectives. The aim of this study is to analyze the distribution of the methylenetetrahydrofolate reductase enzyme (MTHFR) rs1801133 (C677T) genotype and allele distribution in a Turkish professional cyclist cohort. Methods. There were 25 Turkish cyclists enrolled in the study. Peripheral blood used for DNA isolation and the conventional polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP) methodology were used for genotyping. Results. There were 14 (56%), 10 (40%) and 1 (4%) cyclist who had CC, CT, and TT genotypes, respectively. C allele was counted as 38 (76%), and T alleles as 12 (24%). 9 (50%) of the male cyclist had CC, 8 (44.4%) had CT and only 1 had TT (5.6%) genotypes. C allele was counted as 26 (72.2%), and the T allele as 10 (27.8%) in the male cyclists. In the females, the respective genotypes for CC and CT were 5 (71.4%) and 2 (28.6%). C allele was counted as 12 (85.7%) and T allele as 2 (14.3%). Conclusion. In our cohort, both of the two genders, the CC genotype and C allele were found to be higher when compared to the other genotypes and T allele. Larger prospective studies focusing on the influence of MTHFR rs1801133 polymorphism in athletic performance are required for confirmation of our findings.

中文翻译：

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亚甲基四氢叶酸还原酶rs1801133多态性在土耳其专业自行车手群体中的分布

背景。确定体育运动表现的遗传end赋是开发个人训练课程或营养补充品以取得成功的重要一步。有关负责这些新陈代谢的遗传参数的信息将帮助体育科学家开发新见解，以取得更好的表现。肌肉代谢是改善个人运动成绩的关键点之一。目标。这项研究的目的是分析土耳其专业自行车运动员群体中亚甲基四氢叶酸还原酶（MTHFR）rs1801133（C677T）基因型的分布和等位基因分布。方法。这项研究有25名土耳其自行车手参加。用于DNA分离的外周血和常规的聚合酶链反应限制性片段长度多态性（PCRRFLP）方法用于基因分型。结果。分别有CC，CT和TT基因型的14（56％），10（40％）和1（4％）自行车手。C等位基因计数为38（76％），T等位基因计数为12（24％）。男性自行车骑行者中有9名（50％）患有CC，8名（44.4％）具有CT，只有1名具有TT（5.6％）基因型。在男性骑自行车者中，C等位基因计为26（72.2％），T等位基因计为10（27.8％）。在女性中，CC和CT的基因型分别为5（71.4％）和2（28.6％）。C等位基因计数为12（85.7％），T等位基因计数为2（14.3％）。结论。在我们的队列中，发现两个性别的CC基因型和C等位基因均高于其他基因型和T等位基因。