Purpose: Stroke is a global economic burden of health, which means that it is critical to evaluate changes of optimal diagnoses and treatments. The aim of the study reported herein was to identify the most-cited articles in the field of ischemic stroke and assess their characteristics. Methods: We searched all included articles that had been cited more than 100 times using the “Cited Reference Search” in February 2016 from Web of Science Core Collection. Among a total of 2,651 articles, we excluded articles on basic science and which involved only hemorrhagic strokes and identified the top-100 cited articles on ischemic stroke. Results: The number of citations for the articles analyzed in this study ranged from 5,182 to 580. Most of the articles were published in The Lancet (25%) and Stroke (23%), and originated from the United States of America (n= 44). Most of them were original articles (65%) and dealt with stroke risk factors (32%) and stroke management (30%). A novel study of hyperacute treatment involving recombinant-tissue plasminogen activator was described in the top-ranked article. Conclusion: Reviews on highly cited articles can help physicians identify trends in the diagnosis and treatment of ischemic stroke in the past. This bibliometric analysis can provide a unique perspective on historical developments in this field.

中文翻译：

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基于高被引文章的缺血性卒中的历史诊断和治疗变化

目的：中风是全球健康的经济负担，这意味着评估最佳诊断和治疗的变化至关重要。本文报告的研究的目的是确定缺血性中风领域中引用最多的文章并评估它们的特征。方法：我们使用 2016 年 2 月的“被引参考文献检索”从 Web of Science 核心合集中检索了所有被引用超过 100 次的纳入文章。在总共 2,651 篇文章中，我们排除了基础科学和仅涉及出血性卒中的文章，并确定了前 100 篇关于缺血性卒中的引用文章。结果：本研究中分析的文章被引用次数从 5,182 到 580 不等。大多数文章发表在《柳叶刀》（25%）和《中风》（23%）上，并且起源于美利坚合众国（n=44）。其中大部分是原创文章（65%），涉及中风危险因素（32%）和中风管理（30%）。排名靠前的文章描述了一项涉及重组组织纤溶酶原激活剂的超急性治疗的新研究。结论：对高被引文章的评论可以帮助医生识别过去缺血性卒中的诊断和治疗趋势。这种文献计量分析可以为该领域的历史发展提供独特的视角。对高引用文章的评论可以帮助医生确定过去缺血性卒中诊断和治疗的趋势。这种文献计量分析可以为该领域的历史发展提供独特的视角。对高引用文章的评论可以帮助医生确定过去缺血性卒中诊断和治疗的趋势。这种文献计量分析可以为该领域的历史发展提供独特的视角。