Breast cancer (BC), one of the most frequent human tumors, is genetically and histologically heterogeneous. Treatment options can be adapted according to BC subtype. Still, research is necessary to characterize BC biology better and to study potential new treatment options. Murine BC-cell lines can be used as model systems in this respect. Here for the first time murine BC-cell line JC was cytogenomically characterized as being complex rearranged and near-tetraploid. Multicolor banding and array comparative genomic hybridization were applied and the result was in silico translated to the human genome. Even though being commercially available, cell line JC was yet not much included in BC-research, most likely due to a lack of cytogenomic data. Thus, here comprehensive data is provided on chromosomal aberrations, genomic imbalances and involved breakpoints of JC cell line. Also JC could be characterized as a model for BC of luminal B type, basal-like tumor rather than for luminal A type.

中文翻译：

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小鼠乳腺癌细胞JC的细胞基因组学特征

乳腺癌（BC）是人类最常见的肿瘤之一，在遗传和组织学上都是异质的。可以根据BC亚型调整治疗方案。尽管如此，仍然有必要进行研究以更好地表征BC生物学并研究潜在的新治疗方案。在这方面，小鼠BC细胞系可以用作模型系统。首次在细胞遗传学上将鼠BC细胞系JC表征为复杂的重排和近四倍体。应用多色条带和阵列比较基因组杂交，并将结果通过计算机翻译为人类基因组。尽管可以从市场上买到，但细胞系JC尚未在BC研究中包括在内，这很可能是由于缺乏细胞基因组学数据。因此，这里提供了有关染色体畸变的综合数据，基因组失衡和涉及的JC细胞系断点。同样，JC可以被描述为腔B型，基底样肿瘤的BC模型，而不是腔A型的模型。