Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of angiogenesis modulators in a different milieu. The term angiogenesis or neovascularization refers to the development of de novo vascular buds from the pre-existing blood vessels. This phenomenon is tightly dependent on the balance between the pro- and anti-angiogenesis factors which alters the functional behavior of vascular cells. The promotion of angiogenesis is thought to be an effective strategy to accelerate the healing process of ischemic changes such as infarcted myocardium. Of note, most of the previous studies have focused on the anti-angiogenesis capacity of melatonin in the tumor niche. To the best of our knowledge, few experiments highlighted the melatonin angiogenesis potential and specific regulatory mechanisms in the cardiovascular system. Here, we aimed to summarize some previous experiments related to the application of melatonin in cardiovascular diseases such as ischemic injury and hypertension by focusing on the regulatory mechanisms.

中文翻译：

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褪黑激素在血管生成潜力中的作用；重点关注心血管疾病


褪黑激素具有多器官和多效性作用，能够在分子和细胞水平上控制血管生成。迄今为止，已经做出了许多努力来控制和调节不同环境中血管生成调节剂的动态。术语血管生成或新血管形成是指从预先存在的血管发育出新的血管芽。这种现象紧密依赖于促血管生成因子和抗血管生成因子之间的平衡，从而改变血管细胞的功能行为。促进血管生成被认为是加速梗塞心肌等缺血性变化愈合过程的有效策略。值得注意的是，之前的大多数研究都集中在肿瘤微环境中褪黑激素的抗血管生成能力。据我们所知，很少有实验强调褪黑激素血管生成的潜力和心血管系统中的特定调节机制。在此，我们旨在以调节机制为重点，总结一些以往褪黑素在缺血性损伤、高血压等心血管疾病中应用的相关实验。