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A Mini-review of Computational Approaches to Predict Functions and Findings of Novel Micro Peptides
Current Bioinformatics ( IF 2.4 ) Pub Date : 2020-10-31 , DOI: 10.2174/1574893615999200811130522
Mohsin Ali Nasir 1 , Jian Huang 1 , Samia Nawaz 1
Affiliation  

New techniques in bioinformatics and the study of the transcriptome at a wide-scale have uncovered the fact that a large part of the genome is being translated than recently perceived thoughts and research, bringing about the creation of a various quantity of RNA with proteincoding and noncoding potential. A lot of RNA particles have been considered as noncoding due to many reasons, according to developing proofs. Like many sORFs that encode many functional micro peptides have neglected due to their tiny sizes.

Advanced studies reveal many major biological functions of these sORFs and their encoded micro peptides in a different and wide range of species. All the achievement in the identification of these sORFs and micro peptides is due to the progressive bioinformatics and high-throughput sequencing methods. This field has pulled in more consideration due to the detection of a large number of more sORFs and micro peptides. Nowadays, COVID-19 grabs all the attention of science as it is a sudden outbreak. sORFs of COVID-19 should be revealed for new ways to understand this virus. This review discusses ongoing progress in the systems for the identification and distinguishing proof of sORFs and micro peptides.



中文翻译:

预测新型微肽功能和发现的计算方法的简要回顾

生物信息学的新技术和大规模的转录组研究发现了这样一个事实,即基因组的很大一部分正在被翻译,而不是最近的思想和研究,从而创造了具有蛋白质编码和非编码形式的各种RNA。潜在。根据开发证据,由于许多原因,许多RNA颗粒被认为是非编码的。像许多编码许多功能性微肽的sORF一样,由于其微小的尺寸而被忽略了。

先进的研究揭示了这些sORF及其许多不同种类物种中编码的微肽的许多主要生物学功能。鉴定这些sORF和微型肽的所有成就归功于先进的生物信息学和高通量测序方法。由于检测到更多的sORF和微肽,这一领域引起了更多的考虑。如今,COVID-19突然爆发就吸引了科学的所有关注。应该揭示COVID-19的sORF,以了解该病毒的新方法。这篇综述讨论了用于鉴定和区分sORF和微肽的证据的系统的持续进展。

更新日期:2020-10-31
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