Abstract

The efficient total syntheses of four biologically interesting natural glucosides Ethylconiferin, Butylconiferin, 2’-Butoxyethylconiferin and Balajaponin B, have been achieved for the first time starting from commercially available Vanilline via concise reaction sequence of 8–10 steps with the overall yield of 26–41%. This work definitely laid the foundation for the further pharmacological study of this kind of natural compounds. Meanwhile, currently developed approach could be used as a general synthetic strategy for the syntheses of other monolignol glucosides and their derivatives, and provides an opportunity for further study of the structure-activity relationship of this kind of glucosides.

中文翻译：

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四种天然生物活性糖苷的首次总合成

摘要

从市售的香兰素开始，经过8-10个步骤的简捷反应序列，总产率为26- 41％。这项工作无疑为进一步研究这种天然化合物奠定了基础。同时，目前开发的方法可以用作合成其他单木酚糖苷及其衍生物的一般合成策略，并为进一步研究这种糖苷的构效关系提供了机会。