Abstract

2-Amino-3-cyanopyridine derivatives were synthesized in an ultrasonic bath and one pot four-component reactions with high yields, in a short time, without solvent and catalyst, and anticancer activity studies on MCF7, DU145, and HepG2 cell lines were investigated. 18 compounds were synthesized in 4–25 min time interval and 85–99% yield. Among these compounds, the IC50 values in 7a, 6a, and 3a on MCF7 breast cancer cell line was found to be 1.80, 1.95, and 2.50 µM, respectively, while the values in the HepG2 liver cancer cell line were 7.71, 7.90, and 8.05 µM, respectively. In studies conducted in the DU145 prostate cancer cell line, IC50 values of compounds 1b, 2b, and 8b were found to be 9.90, 10.10, and 15.30 µM, respectively.

摘要

在没有溶剂和催化剂的情况下，在超声波浴和一锅四组分反应中以高产率，短时间合成2-氨基-3-氰基吡啶衍生物，并研究了其对MCF7，DU145和HepG2细胞系的抗癌活性。在4-25分钟的时间间隔内合成了18种化合物，产率为85-99％。在这些化合物中，发现MCF7乳腺癌细胞系中7a，6a和3a的IC50值分别为1.80、1.95和2.50 µM，而HepG2肝癌细胞系中的IC50值分别为7.71、7.90和3.50 µM。分别为8.05 µM。在DU145前列腺癌细胞系中进行的研究中，化合物1b，2b和8b的IC50值 分别为9.90、10.10和15.30 µM。