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In-vitro Degradation Behaviors of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Microspheres
Journal of Macromolecular Science Part B-Physics ( IF 1.2 ) Pub Date : 2021-02-02
Meiling Yi, Zhihua Zhou, Wenjuan Liu, Tianlong Huang, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Chao Zhang, Jianjun Fang

Abstract

Among drug delivery systems, polymer microspheres have been proved to be the most promising carriers during the past several years. In this paper we describe the preparation of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) random terpolymer microspheres; their in-vitro degradation behaviors, including the changes of pH value, mass loss, molecular mass and surface morphology, were investigated during various degradation periods and compared with poly(lactic-co-glycolic acid) (PLGA) microspheres. The results showed that the introduction of the ε-caprolactone (ε-CL) unit reduced the degradation rate of the PLGA polymers. Therefore, we suggest the PLLGC microspheres with controllable degradation rate could supply a wider application future in drug delivery field than pure PLGA microspheres.



中文翻译:

聚(L-丙交酯-乙交酯-ε-己内酯)微球的体外降解行为

摘要

在药物输送系统中,聚合物微球在过去几年中被证明是最有前途的载体。在本文中,我们描述了聚(L-丙交酯-乙交酯-ε-己内酯)(PLLGC)无规三元共聚物微球的制备;在不同降解期间研究了它们的体外降解行为,包括pH值的变化,质量损失,分子质量和表面形态,并与聚乳酸-乙醇酸(PLGA)微球进行了比较。结果表明,ε-己内酯(ε-CL)单元的引入降低了PLGA聚合物的降解率。因此,我们认为降解速率可控的PLLGC微球比纯PLGA微球可以在药物输送领域提供更广阔的应用前景。

更新日期:2021-02-02
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