A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.

提出了一种连续流工艺，该工艺能够在光化学条件下安全地生成和衍生苯并。新型高功率LED灯可发出365 nm的光，从而促进了这种情况。所得的流动过程基于可调节的背压调节器有效地控制了气态副产物的释放，并在3分钟的短停留时间内交付了一系列杂环产物。证明了该方法的鲁棒性，可快速生成苯并三唑，2 H-吲唑和各种呋喃衍生的加合物，从而通过简单且易于扩展的流动方案促进了这些重要杂环骨架的制备。