The role of miR‐29 family in disease,Journal of Cellular Biochemistry

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The role of miR‐29 family in disease
Journal of Cellular Biochemistry ( IF 3.0 ) Pub Date : 2021-02-02 , DOI: 10.1002/jcb.29896
Masahiro Horita ₁ , Colin Farquharson ₁ , Louise A Stephen ₁

Affiliation

MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3’‐untranslated region of messenger RNA to regulate posttranscriptional gene expression. Increasing evidence has identified the miR‐29 family, consisting of miR‐29a, miR‐29b‐1, miR‐29b‐2, and miR‐29c, as key regulators of a number of biological processes. Moreover, their abnormal expression contributes to the etiology of numerous diseases. In the current review, we aimed to summarize the differential expression patterns and functional roles of the miR‐29 family in the etiology of diseases including osteoarthritis, osteoporosis, cardiorenal, and immune disease. Furthermore, we highlight the therapeutic potential of targeting members of miR‐29 family in these diseases. We present miR‐29s as promoters of osteoblast differentiation and apoptosis but suppressors of chondrogenic and osteoclast differentiation, fibrosis, and T cell differentiation, with clear avenues for therapeutic manipulation. Further research will be crucial to identify the precise mechanism of miR‐29 family in these diseases and their full potential in therapeutics.

中文翻译：

miR-29家族在疾病中的作用

MicroRNA 是小的非编码 RNA，可以与信使 RNA 的 3' 非翻译区的靶位点结合以调节转录后基因的表达。越来越多的证据表明，由 miR-29a、miR-29b-1、miR-29b-2 和 miR-29c 组成的 miR-29 家族是许多生物过程的关键调节因子。此外，它们的异常表达促成了许多疾病的病因学。在当前的综述中，我们旨在总结 miR-29 家族在包括骨关节炎、骨质疏松症、心肾和免疫疾病在内的疾病病因学中的差异表达模式和功能作用。此外，我们强调了在这些疾病中靶向 miR-29 家族成员的治疗潜力。我们将 miR-29s 作为成骨细胞分化和凋亡的促进剂，但作为软骨形成和破骨细胞分化、纤维化和 T 细胞分化的抑制剂，为治疗操作提供了明确的途径。进一步的研究对于确定 miR-29 家族在这些疾病中的精确机制及其在治疗中的全部潜力至关重要。

更新日期：2021-02-02

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