Treatment‐resistant depression (TRD) is a debilitating chronic mental illness that confers increased morbidity and mortality, decreases the quality of life, impairs occupational, social, and offspring development, and translates into increased costs on the healthcare system. The goal of this study is to reach an agreement on the concept, definition, staging model, and assessment of TRD.

中文翻译：

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难治性重度抑郁症：加拿大专家对定义和评估的共识

抗药性抑郁症（TRD）是一种使人衰弱的慢性精神疾病，它会增加发病率和死亡率，降低生活质量，损害职业，社会和后代的发展，并转化为医疗保健系统的成本增加。这项研究的目的是就TRD的概念，定义，分期模型和评估达成共识。