Purpose

To compare lens cleaning routines using a povidone iodine-based rigid lens disinfecting solution and its effect on conjunctival colonisation, and lens and lens case contamination.

Methods

Participants, aged 6–10 years, receiving orthokeratology treatment were randomised to four lens cleaning routines: with and without the use of daily and/or weekly cleaners, which were performed by their parents. Conjunctival colonisation was compared before lens wear and at 1-, 3-, and 6-month after commencement of lens wear. Contamination of lenses and lens cases was investigated at these times. Organisms were identified using MALDI-TOF mass spectrometry.

Results

Of the 76 participants who completed the study, conjunctival colonization was present in 24 (32 %) at baseline. Of the remaining 52 participants, 34 consistently yielded no growth. Participants positive at baseline were statistically more likely to be colonized after commencement of lens wear (p = 0.020). Overall, colonization rate was reduced to 15 % (11/72) after 6-month lens wear, which reached significance for initially colonized participants (p < 0.001). Few cultures yielded potential ocular pathogens, with notably no Pseudomonas aeruginosa. Contamination rates of both lenses and lens cases were also low, with few isolations of ocular pathogens. No significant differences were observed between cleaning regimes for conjunctival colonization or contamination of lenses or cases.

Conclusions

Disinfection for rigid and ortho-k lens wearers may be effectively achieved with the use of povidone iodine-based solution, apparently regardless of cleaning routine adopted in the current study. The absence of pathogens in the conjunctiva, lenses, and lens cases in the great majority of samples indicates that it can improve the safety of overnight lens wear.

中文翻译：

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聚维酮碘隐形眼镜消毒液对角膜塑形镜及镜盒污染及结膜微生物群落的影响

目的

比较使用基于聚维酮碘的硬质镜片消毒溶液的镜片清洁程序及其对结膜定植以及镜片和镜片盒污染的影响。

方法

接受角膜塑形术治疗的 6-10 岁参与者被随机分配到四种镜片清洁程序中：使用和不使用由父母执行的每日和/或每周清洁剂。在配戴镜片前和开始配戴镜片后 1、3 和 6 个月时比较结膜定植情况。在这些时候调查了镜片和镜片盒的污染。使用 MALDI-TOF 质谱法鉴定有机体。

结果

在完成研究的 76 名参与者中，24 名（32%）在基线时出现结膜定植。在其余 52 名参与者中，34 名一直没有增长。基线时阳性的参与者在开始佩戴镜片后更有可能被定植（p = 0.020）。总体而言，在佩戴 6 个月的镜片后，定植率降至 15% (11/72)，这对最初定植的参与者具有显着性意义 (p < 0.001)。很少有培养物产生潜在的眼部病原体，尤其是没有铜绿假单胞菌。镜片和镜片盒的污染率也很低，几乎没有分离出眼部病原体。在结膜定植或镜片或镜盒污染的清洁方案之间没有观察到显着差异。

结论

使用基于聚维酮碘的溶液可以有效地对硬性镜片和角膜塑形镜佩戴者进行消毒，显然与当前研究中采用的清洁程序无关。在绝大多数样本中，结膜、镜片和镜片盒中没有病原体表明它可以提高过夜配戴镜片的安全性。