With the aim of extending the library of green fluorescent protein chromophore analogs, a facile one-pot synthesis of 5-(diarylmethylene)imidazolones from the corresponding amide or thioamide is described. Isolation of unstable imidate intermediates is not required, thereby circumventing the drawback of previous approaches. A reaction mechanism in which both acetate and acetic acid promote the imidazolone formation is proposed.

中文翻译：

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乙酰胺或硫酰胺的乙酸/乙酸辅助一锅法合成（二芳基亚甲基）咪唑酮

为了扩展绿色荧光蛋白生色团类似物的文库，描述了由相应的酰胺或硫代酰胺容易地一锅合成5-（二芳基亚甲基）咪唑啉酮。不需要分离不稳定的亚氨酸酯中间体，从而避免了先前方法的缺点。提出了乙酸和乙酸都促进咪唑酮形成的反应机理。