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Acetate/Acetic Acid-Assisted One-Pot Synthesis of (Diarylmethylene)imidazolone from Amide or Thioamide
Heterocycles ( IF 0.8 ) Pub Date : 2021-02-01 , DOI: 10.3987/com-20-14396
Masahiro Ikejiri , Kazuyuki Miyashita , Atsufumi Watanabe , Mari Katsuda , Mayu Funakoshi , Aki Fujisaka

With the aim of extending the library of green fluorescent protein chromophore analogs, a facile one-pot synthesis of 5-(diarylmethylene)imidazolones from the corresponding amide or thioamide is described. Isolation of unstable imidate intermediates is not required, thereby circumventing the drawback of previous approaches. A reaction mechanism in which both acetate and acetic acid promote the imidazolone formation is proposed.

中文翻译:

乙酰胺或硫酰胺的乙酸/乙酸辅助一锅法合成(二芳基亚甲基)咪唑酮

为了扩展绿色荧光蛋白生色团类似物的文库,描述了由相应的酰胺或硫代酰胺容易地一锅合成5-(二芳基亚甲基)咪唑啉酮。不需要分离不稳定的亚氨酸酯中间体,从而避免了先前方法的缺点。提出了乙酸和乙酸都促进咪唑酮形成的反应机理。
更新日期:2021-04-01
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