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Evaluation of antiproliferative potential of manganese (II)-dafone complex
Indian Journal of Biochemistry and Biophysics ( IF 1.5 ) Pub Date : 2021-02-01
Reena, Megha P Nambiar, Bonige Kishore Babu, AR Biju

Cytotoxicity is the quality of being toxic to cells. In vitro toxicity is the scientific analysis of the effect of toxic chemical substances on cultured bacteria or mammalian cells. In our work Manganese–4,5-Diazafluoren-9-one complex was prepared and its cytotoxicity was studied by standard MTT Assay in Cervical carcinoma cells HeLa. The result was compared with the normal fibroblast cell to check its influence on normal cells. On comparing the results, the complex is found to be more toxic to cervical carcinoma cells than the normal fibroblast cells. The photocatalytic activity of the complex was studied on the basis of the decomposition reaction of methylene blue dye in presence of the complex. The compound [Mn(C11H6N2O)2(NCS)2] was synthesised and characterised by various spectroscopic methods and the structure was confirmed by single- crystal XRD analysis. The molecular structure of the complex was optimized using density functional theory (DFT) at the B3LYP/6–311 G (d,p) level. The smallest HOMO–LUMO energy gap (0.66 eV) indicates the soft acid nature of the complex.

中文翻译:

锰(dafone)复合物的抗增殖潜力评估

细胞毒性是对细胞有毒性的性质。体外毒性是对有毒化学物质对培养细菌或哺乳动物细胞影响的科学分析。在我们的工作中,制备了锰–4,5-二氮杂芴-9-1配合物,并通过标准MTT分析法研究了其在宫颈癌细胞HeLa中的细胞毒性。将结果与正常成纤维细胞进行比较,以检查其对正常细胞的影响。在比较结果时,发现该复合物对宫颈癌细胞的毒性比正常的成纤维细胞高。基于亚甲基蓝染料在配合物存在下的分解反应,研究了配合物的光催化活性。化合物[Mn(C 11 H 6 N 2 O)合成了2(NCS)2 ]并通过各种光谱方法表征,并通过单晶XRD分析确认了结构。使用密度泛函理论(DFT)在B3LYP / 6–311 G(d,p)水平上优化了复合物的分子结构。最小的HOMO-LUMO能隙(0.66 eV)表明了该复合物的软酸性质。
更新日期:2021-02-01
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