The influence of different biological agents on the rate of orthodontic tooth movement (OTM) has been extensively reviewed in animal studies with conflicting results. These findings cannot be extrapolated from animals to humans. Therefore, we aimed to systematically investigate the most up-to-date available evidence of human studies regarding the effect of the administration of different biological substances on the rate of orthodontic tooth movement. A total of 8 databases were searched until the 16th of June 2020 without restrictions. Controlled randomized and non-randomized human clinical studies assessing the effect of biological substances on the rate of OTM were included. ROBINS-I and the Cochrane Risk of Bias tools were used. Reporting of this review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 11 studies (6 randomized clinical trials and 5 prospective clinical trials) were identified for inclusion. Local injections of prostaglandin E1 and vitamin C exerted a positive influence on the rate of OTM; vitamin D showed variable effects. The use of platelet-rich plasma and its derivatives showed inconsistent results, while the local use of human relaxin hormone showed no significant effects on the rate of OTM. The limited and variable observation periods after the administration of the biological substances, the high and medium risk of bias assessment for some included studies, the variable concentrations of the assessed biological agents, the different experimental designs and teeth evaluated, and the variety of measurement tools have hampered the quantitative assessment of the results as originally planned. Despite the methodological limitations of the included studies, this systematic review provides an important overview of the effects of a variety of biological agents on the rate of tooth movement and elucidates the deficiencies in the clinical studies that have been conducted so far to evaluate the effectiveness of these agents in humans, providing some guidelines for future robust research. PROSPERO ( CRD42020168481 , www.crd.york.ac.uk/prospero )

中文翻译：

---

局部施用生物物质对正畸牙齿移动率的影响：人体研究的系统回顾


不同生物制剂对正畸牙齿移动 (OTM) 速率的影响已在动物研究中得到广泛回顾，但结果相互矛盾。这些发现不能从动物推断到人类。因此，我们的目的是系统地调查关于不同生物物质的施用对正畸牙齿移动率的影响的人类研究的最新可用证据。截至2020年6月16日，共检索8个数据库，无限制。其中包括评估生物物质对 OTM 率影响的对照随机和非随机人类临床研究。使用了 ROBINS-I 和 Cochrane 偏差风险工具。本次审查的报告基于系统审查和荟萃分析的首选报告项目 (PRISMA) 指南。共有 11 项研究（6 项随机临床试验和 5 项前瞻性临床试验）被确定纳入。局部注射前列腺素E1和维生素C对OTM发生率有积极影响；维生素 D 表现出不同的效果。使用富含血小板的血浆及其衍生物显示出不一致的结果，而局部使用人松弛素激素对OTM率没有显着影响。生物物质施用后的有限且可变的观察期、某些纳入研究的偏倚评估的高和中风险、评估的生物制剂的可变浓度、不同的实验设计和评估的牙齿以及各种测量工具妨碍了按原计划对结果进行定量评估。 尽管纳入的研究存在方法学上的局限性，但这项系统综述提供了各种生物制剂对牙齿移动速率的影响的重要概述，并阐明了迄今为止为评估生物制剂有效性而进行的临床研究中的缺陷。这些药物在人体中的作用，为未来的稳健研究提供了一些指导。普罗斯佩罗（CRD42020168481，www.crd.york.ac。英国/普洛斯彼罗）