Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generated. Organoids are applied widely in development, disease modelling, regenerative medicine, and other multiple aspects. Various human pulmonary diseases caused by several factors can be induced and lead to different degrees of lung epithelial injury. Epithelial repair involves the participation of multiple cells and signalling pathways. Lung organoids provide an excellent platform to model injury to and repair of lungs. Here, we review the recent methods of cultivating lung organoids, applications of lung organoids in epithelial repair after injury, and understanding the mechanisms of epithelial repair investigated using lung organoids. By using lung organoids, we can discover the regulatory mechanisms related to the repair of lung epithelia. This strategy could provide new insights for more effective management of lung diseases and the development of new drugs.

中文翻译：

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肺类器官，研究肺损伤后上皮修复的有用工具

类器官来自干细胞或器官特异性祖细胞。它们显示与体内器官一致的结构和功能。可以生成多种类型的类器官，包括肺类器官。类器官在开发，疾病建模，再生医学和其他多个方面得到广泛应用。可以诱发由多种因素引起的各种人类肺部疾病，并导致不同程度的肺上皮损伤。上皮修复涉及多个细胞和信号通路的参与。肺类器官为模拟肺部损伤和修复提供了一个极好的平台。在这里，我们综述了培养肺类器官的最新方法，损伤后上皮修复中肺类器官的应用以及了解使用肺类器官研究的上皮修复机制。通过使用肺类器官，我们可以发现与修复肺上皮有关的调节机制。该策略可以为更有效地管理肺部疾病和开发新药物提供新的见解。